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An Update of the Structure-Activity Relationship and Efficacy in the Treatment of Poisoning with Organophosphorus Compounds. Front Med Chem.
The early causes of death in organophosphorus compound poisonings are chiefly related to ventricular arrhythmias, CNS depression, seizures, or respiratory failure due to excessive bronchial secretions, bronchospasm, pulmonary oedema, aspiration of gastric contents, paralysis of respiratory muscles, or apnoea associated with depression of the medullary respiratory center.
Poisoning with organophosphorus compound (OPC): Mythology vs.
Sol-gel silica waveguides have been used as biophotonic sensors to detect organophosphorus compounds such as sarin and insecticide.
121 patients were studied and found that the levels of serum LDH and creatine kinase levels were markedly elevated among poisoning cases indicating muscular impairment due to organophosphorus compound toxicity.
Type II Paralysis or Intermediate Syndrome: It follows the intense cholinergic crisis of organophosphorus poisoning and occurs in up 20%-50% of cases depending on the severity of poisoning, its duration, and on the type of organophosphorus compound. The pathogenesis is presumed to be dysfunction of neuromuscular junction caused by down regulation of presynaptic and postsynaptic Nicotinic receptors due to release of excessive Ach and Ca2+ respectively.3 The cardinal features comprise muscular weakness, affecting predominantly the proximal limbs muscles and neck flexors.
The organophosphorus compound paraoxon (Toronto Research Chemicals) was the reactant (substrate) used for OPUtoxTM (Reactive Surfaces Ltd., Texas).
Albright & Wilson's Antiblaze 1045 flame retardant is a high-molecular-weight organophosphorus compound designed for polyamides and polyesters.
Then the chemicals would be mechanically mixed, creating the lethal nerve as VX, the same organophosphorus compound contained in the United States' older, stockpiled "unitary" (premixed) chemical weapons.
Present study shows the importance of WHO staging of severity of Organophosphorus compound poisoning, as the mortality increases with severity.
Organophosphorus compound poisoning; epidemiology and management (atropinisation Vs pralidoxime): a descriptive analysis in allied hospital Faisalabad.
The predominant mode of attempted suicide in our study has been organophosphorus compound poisoning with incidence of 57% followed by rat poisoning at 8% and hanging at 7% as third important mode.

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