Nearly 100% of patients were having fever, 13.74% of patients were having headache, 19.08% were having vomiting, 22.9% of patients were having abdominal pain, 22.9% of patients were having skin rash, 21.37% of patients were having bleeding manifestations, 20.61% of patients were having fluid accumulation, 25.19% of patients were having organomegaly
, 6.1% of patients were having GB wall thickening, and 3.05% of patients were having liver abscess.
in 2010. In the beginning, TAFRO stood for Thrombocytopenia (T), Anasarca (A), Fever (F), Reticulin fibrosis (R), and Organomegaly
(O) which was consistent with the clinical presentation of our patient. In 2012, a diagnostic criterion was proposed for TAFRO syndrome at the Fukushima and Nagoya meeting, and some slight changes were made for the acronyms: F presented myelofibrosis and R for renal dysfunction. This criterion was composed of 11 items [Table 1] which included both clinical and laboratory parameters.
Other associated complaints included abdominal fullness with no significant organomegaly
, non-specific cough, diaphoresis and loss of weight.
Diagnostic criteria of TAFRO syndrome  include presence of histological criteria (compatible with pathological findings of lymph node as TAFRO-iMCD and negative LANA-1 for HHV8), three of five major criteria (thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly
), and one of two minor criteria (hyper/normoplasia of megakaryocytes in bone marrow or high levels of serum ALP without markedly elevated serum transaminase) which are needed to meet the diagnosis of TAFRO syndrome.
She had no other symptoms, organomegaly
, or lymphadenopathy.
The patient had an extensive and complex medical history that included non-Hodgkin's lymphoma, now in remission; an illness diagnosed by some as POEMS syndrome (polyneuropathy, organomegaly
, endocrinopathy, circulating M protein, and skin changes) and by other physicians as Waldenstrom's macroglobulinemia; hepatic cirrhosis with a TIPS procedure (transjugular intrahepatic portosystemic shunt), a TIPS revision, and at least one episode of hepatic encephalopathy; systemic arterial hypertension; diabetes mellitus; and mild chronic renal insufficiency.
He also had clinically demonstrable ascites with no organomegaly
. His pulse was 72 beats/min, BP 100/60 mm Hg and neck veins were not engorged.
There was no peripheral lymphadenopathy and abdomen was soft and non-tender with no organomegaly
. Chest examination was unremarkable.
Conclusion: Using ERT was safe and effective in the reversal of hematological complications and organomegaly
in most of the patients.
Tier body temperature and breathing sounds were normal, and there was no organomegaly
In a study by Robert and colleagues (8) to determine the visceral risk secondary to a direct percutaneous puncture of the upper renal calyx utilizing magnetic resonance imaging, the authors reported that liver or spleen injury was unlikely to happen in the case of classical punctures below the 12th rib, particularly in the absence of organomegaly
. Our approach was well below the 12th rib targeting a lower pole calyx containing the stone, but his liver span measured 20 cm.
He was asymptomatic and had no organomegaly
. Blood tests showed lymphocytosis of 35x[10.sup.9]/L.