Ustekinumab response rates were sustained through one year in organ-specific
disease measures (>=50% improvement in active joint counts: week 24: 87% vs week 48: 87%; >=50% improvement in CLASI activity score: week 24: 53% vs week 48: 69%).
The autoimmune mechanisms leading to EIMs have been suggested to be related to many factors, including genetic susceptibility, antigenic display of autoantigen, aberrant self-recognition, and immunopathogenetic autoantibodies against organ-specific
cellular antigens shared by the colon and extra-colonic organs.
Our case report emphasizes the importance of a multidisciplinary approach at the onset of organ-specific
manifestations in patients with PAN.
Modest and severe maternal iron deficiency in pregnancy are associated with fetal anaemia and organ-specific
hypoxia in rats.
The expertise in in silico modeling (including toxicokinetic modeling, chemo-and bioinformatics), innovative high throughput platforms, advanced organ-specific
assays, and broad toxicological expertise will be integrated into pragmatic testing strategies for chemical risk assessment.
(3) Among non-ABP-certifiable fellowships, most were surgical pathology related; 51% (n = 187 of 364) were in non-organ-specific surgical pathology (general or surgical/oncology); and 39% (n = 142 of 364) in organ-specific
surgical pathology (breast, cardiovascular, gastrointestinal, genitourinary, gynecologic, pulmonary, renal, soft tissue), with the most frequent being gastrointestinal pathology (reported by 8% of respondents, n = 56 of 699).
The researchers pointed to some study limitations, for example, numbers of organ-specific
cancers were relatively small.
From then on, we can identify peculiar characteristics of the organ-specific
or tissue-specific immune responses that include the immune responses (i) at the epithelial or mucosal barrier (skin and gastrointestinal tract,ii) in a complex organ (liver), and (ii) in organs with immunological privilege (brain and eyes) [2-5].
However, over the past decade, mounting evidence has demonstrated that macrophages are also derived from embryonic York sac and fetal liver and become a self-maintaining population residing locally and performing organ-specific
Exposure to clindamycin and doxycycline during the first trimester may be associated with an increased risk of organ-specific
malformations such as ventricular/atrial septal defect, new research suggests.
Jakus et al., "'Tissue Papers' from Organ-Specific
Decellularized Extracellular Matrices," Advanced Functional Materials, 2017; 1700992 DOI: 10.1002/adfm.201700992