The output variables are transformed using the guidelines of the American Joint Committee on Cancer (AJCC), which were used to identify the pathologic stage as
organ-confined disease (OCD; pT2+) or non-organ-confined disease (NOCD; pT3+ or N+) [23].
These authors did not detect difference in preoperative and pathologic predictors of
organ-confined disease and BCR between men aged <50 years and older [14].
(4,5) In RCC, nephron-sparing surgery is advocated in
organ-confined disease where previously RN would have been routine practice.
(9,10) PSA testing had a significant impact in diagnosing early,
organ-confined disease (11) despite low sensitivity and specificity.
(3) Also in our opinion, patients with truly clinically
organ-confined disease may be reserved for adjuvant chemotherapy (AC); because at least in theoretical basis AC should be equally effective as NAC in this group of patients.
Among the enrolled patients, 302 were diagnosed with
organ-confined disease (T1-2N0 M0), whereas 56 had a distant metastasis (any T, any N, and M1).
But now, the rise in rates of cure because of the likelihood of having an
organ-confined disease has ended.
The results support findings from a previous longitudinal, population-based study of nearly 29,000 men that suggested obesity may protect against development of
organ-confined disease. This does not mean that it's okay to be obese, he cautioned.
(six months post-treatment,
organ-confined disease, Internet user/online support, 40-50 years) That's how men are.
They found that a ratio of free to total PSA less than 0.0765 could distinguish patients with extracapsular extension (ECE) from those with
organ-confined disease (OCD), with a sensitivity of 100% and a specificity of 93%.
We have no similar system with males that sort of says, "Well, every couple of years you go and see a doctor." (Six months post-treatment,
organ-confined disease, 40-50 years) This sort of macho thing....
In patients with
organ-confined disease (pT1a-pT2b), PSA and hK2 were detected in 6 of 10 patients, whereas 3 patients were negative for both PSA and hK2 mRNA.