In recent years, p53 was also found to be at the hub of significantly predicting biological pathways.5 A similar study was done in 2012, according to which, functional status of tumour suppressor p53 was important in progression of CaP.4 It was detected that p53 was genetically altered in histological localised organ-confined
CaP as well as non-organ-confined CaP and distant metastasis.27 Our results suggest that expression of p53 was significantly decreased in CaP.
- The US Food and Drug Administration has granted fast track designation to Lexington, Massachusetts-based urology therapeutics developer Taris Biomedical LLC for TAR-200 (GemRIS) for the treatment of patients with organ-confined
or locally-advanced muscle invasive bladder cancer (MIBC) who are unfit for curative intent therapy, the company said.
In almost 3/4 of cases, PCa was organ-confined
and Gleason score was [less than or equal to]6 in 60% of patients.
The output variables are transformed using the guidelines of the American Joint Committee on Cancer (AJCC), which were used to identify the pathologic stage as organ-confined
disease (OCD; pT2+) or non-organ-confined disease (NOCD; pT3+ or N+) .
 with a sample of 237 patients showed similar results regarding organ-confined
disease (91.6%), but with a lower rate of Gleason score 7 (9%).
Survival rates for 5-year are 70-80% for organ-confined
disease and 20-30% for extravesical disease.
These authors did not detect difference in preoperative and pathologic predictors of organ-confined
disease and BCR between men aged <50 years and older .
adrenal-sparing), which was expected given the excellent prognosis with pT1a tumours, as was the case in our series with organ-confined
(9,10) PSA testing had a significant impact in diagnosing early, organ-confined
disease (11) despite low sensitivity and specificity.
The usefulness of PSA as an early detector of prostate cancer by itself is questionable, owing to the overlap in PSA values seen in patients with BPH and in those with organ-confined
(3) Also in our opinion, patients with truly clinically organ-confined
disease may be reserved for adjuvant chemotherapy (AC); because at least in theoretical basis AC should be equally effective as NAC in this group of patients.
Among the enrolled patients, 302 were diagnosed with organ-confined
disease (T1-2N0 M0), whereas 56 had a distant metastasis (any T, any N, and M1).