orexins


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Related to orexins: suvorexant

orexins

(o-rek-sinz)
Neuropeptides produced by the hypothalamus that influence sleep and wakefulness.
Synonym: hypocretins; hypocretin
References in periodicals archive ?
Neurons located in the lateral hypothalamic (LH) area, the dorsomedial nucleus of the hypothalamus and perifornical hypothalamus produce orexins (OX-A and OX-B), also named hypocretins.
It is an attempt at unraveling possible unexplained areas entailing two neuromodulators, orexin, and nociceptin, to look into their respective effects on the HPA axis, psychological stress, and sepsis-related stress responses.
Ozsoy S, Olguner Eker O, Abdulrezzak U, Esel E, Relationship between orexin A and childhood maltreatment in female patients with depression and anxiety, Soc Neurosci.
Orexins are produced in a particular area of the hypothalamus, including the caudal lateral hypothalamus and adjacent perifornical area [12] and, from these sites, orexin projects throughout the other areas of the brain.
The actions of orexins are mediated by two receptors, orexin-1 (OX1R) and orexin-2 (OX2R) receptors.
Because orexin antagonists have not been used outside of clinical trials, it is too soon to tell whether suvorexant will have the ideal real-world efficacy and safety profile to make it a first-line treatment for insomnia patients, or if it will be reserved for those who have failed a trial of several other treatments.
Headquarters: Tokyo, CEO: Haruo Naito, "Eisai") announced today that it has presented data from a Phase II clinical study (Study 201) on its in-house-developed investigational dual orexin receptor antagonist (DORA) E2006 in patients with insomnia disorder at the 53rd American College of Neuropsychopharmacology (ACNP) Annual Meeting held from December 7 through 11, 2014, in Phoenix, Arizona in the United States.
The neurons expressing orexins were spread throughout the hypothalamus, and their fibers extended to the brain stream and thalamus, suggesting some central physiological effects of orexins.
2009, Role of lateral hypothalamic orexin neurons in reward processing and addiction, Neuropharmacology, 56, Suppl 1, 112-121.
Orexins are neuropeptides (chemical messengers) that are released by specialized neurons in the hypothalamus region of the brain and are believed to be an important regulator of the brain's sleep-wake process.
Furthermore, other studies showed that orexins suppressed the pulsatile secretion of LH in ovariectomized female rats (Tamura et al.
7) Intracerebroventricular injection of anti-orexin antiserum prior to the NPY injection significantly attenuated NPY-induced feeding, indicating that NPY interacts with orexins anatomically and functionally.