The experts think Thomas's orexin
(a cell in the hypothalamus, which controls the sleep/wake function) was destroyed after a strep throat when the body had an autoimmune reaction and destroyed these cells,'' she said.
The drug competitively binds to two subtypes of orexin
neuron receptors, interfering with orexin
neurotransmission to facilitate sleep onset and maintenance.
neural system was discovered in the late 1990s, Dr.
Previous work by the group found that glucose blocks orexin
cells (which was cited as a reason for after-meal sleepiness), and so the researchers also looked at interactions between sugar and protein.
All the tissues were incubated with a primary antibody recognizing the Orexin
Shin-ichiro Imai demonstrated that the protein sirtuin is required in order for calorie restriction to enhance the activity of orexin
, leptin) seem to function as establishing operations in promoting nicotine "craving" in smokers, and nicotine has been postulated to impact appetite (von der Goltz et al.
In the case of mammals, orexigenic activity of ghrelin is mediated by activation of other orexigenic peptides such as NPY, AgRP and orexin
(Toshinai et al.
Suvorexant's mechanism of action in targeting the orexin
system, which promotes wakefulness, sets it apart from some of the currently available sleep medications, according to Dr.
Scientists have found that a mixture similar to egg whites activated brain cells and triggered the release of a stimulant called orexin
An upregulation of the activity of orexin
neurons and changes in appetite regulating hormones may affect food intake.
Merck and Company is investigating a compound that inhibits the action of orexin
receptors, which in turn interfere with the activity of orexin
, a chemical in the brain that produces alertness.