oral tolerance

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oral tolerance

The suppression of autoimmune or allergic responses as a result of eating antigenic material.
See also: tolerance


the ability to endure without effect or injury.

drug tolerance
1. decreased susceptibility to the effects of a drug due to its continued administration.
2. the maximum permissible level of a drug in or on animal feed or food at any particular time relative to slaughter.
high-dose tolerance
in immunology, that induced by the intravenous administration of high doses of aqueous proteins.
immunological tolerance
specific nonreactivity of the immune system to a particular antigen, which is capable under other conditions of inducing an immune response. There is, under normal circumstances, tolerance to self-antigens; identical (monozygotic) twins and dizygotic cattle or sheep twins where there has been placental fusion and exchange of bone marrow stem cells are also tolerant of each other's tissues. Allophenic mice, that is mice produced by fusion of blastocysts from different mice are also tolerant of both 'parents'. The administration of antigens either at high or low dose and infection with certain viruses during critical early stages of immunological development may also induce tolerance.
tolerance level
the concentration of a drug or chemical permitted by law to be present in human food.
tolerance limits
the numerical limits within which a previously identified proportion of values of a variable, or observations in a population, can be expected to occur.
low-dose tolerance
that induced by repeated administration of low doses of the antigen.
oral tolerance
that induced by oral administration of the antigen.
the non-reactivity of the immune system to self-antigens.
tolerance test
see tolerance test.
zero tolerance
when no detectable amount of a chemical substance is permitted in human food.
References in periodicals archive ?
To understand this difference, let's examine how oral tolerance is induced.
This ability to neutralize immune responses--particularly inflammation--simply by consuming a target protein has led researchers to study whether oral tolerance could be used to combat autoimmune disorders.
Oral tolerance, systemic immunoregulation, and autoimmunity.
If oral tolerance works only through T-cell anergy, we might have to find the right part of myelin to feed each person with MS," Weiner said.
President and CEO of AutoImmune, said, "We are pleased to see Teva making a substantial commitment to the development of oral tolerance therapies for autoimmune diseases.
Under the terms of the agreement, Lilly would fund, over several years, the clinical development of oral tolerance products for diabetes, including Phase II and Phase III clinical trials, regulatory submissions, and product registration for AutoImmune's lead diabetes product, AI-401, an oral form of recombinant human insulin.
Continue efforts through Eli Lilly & Company to develop oral tolerance therapy for diabetes.
With highly focused human and capital resources, the Company is developing four product candidates, all based on the principle of oral tolerance.
With highly focused human and capital resources, the Company is developing products based on the principle of oral tolerance.
This trial marks the fifth oral tolerance pharmaceutical to enter human testing.
With highly focused use of its human and capital resources, the Company has successfully brought four product candidates based on the principle of oral tolerance into human clinical testing.