oral glucose tolerance test

Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia.

oral glucose tolerance test



A screening test for diabetes mellitus (DM), in which plasma glucose levels are measured after the patient consumes an oral glucose load. In screening patients for type 2 DM, measuring fasting plasma glucose levels or checking a hemoglobin A1c level is generally preferable to an OGTT because the former tests are simpler, cheaper, and better tolerated by patients. An OGTT reveals type 2 DM when plasma glucose levels exceed 200 mg/dl 2 hr after drinking a 75-g glucose load. Plasma glucose levels between 140 mg/dl and 199 mg/dl suggest impaired glucose tolerance.

Gestational Diabetes Mellitus

In pregnancy, a modified OGTT is used to screen women with risk factors for gestational diabetes (GDM), including obesity, family history of type 2 DM, age greater than 25 years, and a history of unexplained stillbirths. At 24 to 28 weeks' gestation, a 50-g glucose load is given; 1-hr plasma glucose levels greater than 140 mg/dl constitute a positive screening result. Any patient having a positive test result should then undergo a 2-hr, 100-g OGTT to determine whether GDM is present. See: table

Screen high-risk women at first visit, and screen all women at 24–28 weeks' gestation with 75g oral glucose tolerance test. American Diabetes Association revised Standards of Medical Care, published in Diabetes Care special supplement, January 2011. International Association of Diabetes and Pregnancy Study Groups published in Leary, J. et al. (2010). Best Practice Research Clinical Endocrinology and Metabolism 24 (4), 673.
Time:Glucose level exceeds:
Fasting92 mg/dl
60 min180 mg/dl
120 min155 mg/dl
180 min140 mg/dl

oral glucose tolerance test

glucose tolerance test
References in periodicals archive ?
Two oral glucose tolerance tests (OGTT) were conducted 4 hours apart.
The FPG test and the 75-g oral glucose tolerance test (OGTT) are both suitable tests for diabetes," (1) and
Other measures that did not improve in the exercise-only group or the controls but did improve in the other two groups included glucose and insulin response to the oral glucose tolerance test, waist circumference, deep belly fat, triglycerides and adiponectin.
Plasma insulin and glucose responses of healthy subjects to varying glucose loads during three-hour oral glucose tolerance tests.
28] All the more reason for generalists and laboratorians to focus more attention not only on the oral glucose tolerance test but also the hemoglobin Alc assay, which may be useful in diagnosing dysglycemic syndromes of IGT and diabetes.
A total of 446 nondiabetic residents in these villages were followed biannually by oral glucose tolerance test.
SRT501, which targets the SIRT1 enzyme, was found to be safe and well-tolerated, and significantly lowered glucose at the two-hour time point in an oral glucose tolerance test conducted as part of the 28 day Phase 1b trial of patients with Type 2 Diabetes who were naive to treatment.
The authors recommend the oral glucose tolerance test, which although more cumbersome to do, has greater sensitivity and reliability in Asian populations.
Guidelines issued in 2007 by the European Society of Cardiology and the European Association for the Study of Diabetes recommended that physicians routinely perform an oral glucose tolerance test on patients following a MI who had not previously been diagnosed with diabetes (Eur.
All patients without a prior diagnosis of diabetes underwent assessment with an oral glucose tolerance test, following the 2007 recommendation.
For each individual, an oral glucose tolerance test was performed, and lipoprotein profile in peripheral serum samples was determined at 0 weeks, 4 weeks, 8 weeks, 12 weeks and 16 weeks.
8 mg/dL following a 75-g oral glucose tolerance test were seen for the 5-, 25-, and 100-mg doses, respectively, compared with a drop of just 5.