In vivo endoscopic optical biopsy
with optical coherence tomography.
Optical coherence tomography is an optical biopsy
technique that provides highresolution, real-time, cross-sectional imaging of tissues for cystoscopy in bladder cancer, evaluation of kidney morphology and renal masses or detection of extraprostatic invasion in prostate cancer and identification of the neurovascular bundle during radical prostatectomy.
Confocal laser endomicroscopy (CLE) is a sophisticated endoscopic imaging technique introduced in 2004 that allows a so-called optical biopsy
. Two CLE systems are available, the integrated endoscopic system (eCLE, from PENTAX, Tokyo, Japan; Figures 2(a) and 2(b)) and the probe-based system (pCLE, from Mauna Kea Technologies, Paris, France; Figures 2(c) and 2(d)), the latter being passable through the working channel of standard endoscopes.
Speaking at the Opening Plenary at UEG Week, Mori explained that the most remarkable breakthrough with this system is that artificial intelligence enables real-time optical biopsy
of colorectal polyps during colonoscopy, regardless of the endoscopists' skill.
These include optical biopsy
, surgical robots, smart bandage, super-resolution microscopy, proton beam therapy, artificial organs, neurostimulation, tactile imaging, X-eluting stents, and 3D medical imaging.
Based on the narrative summarized above, optical imaging is still in its infancy and it seems that optical biopsy
is the next step in medical imaging, providing solutions to the limitations of conventional modalities .
Conversely, OCT in vivo noninvasive optical biopsy
enables real-time imaging with high resolution similar to a standard histological examination without the need for tissue removal .
In other words, an 'optical biopsy
' of the microstructure retinal tissues could be achieved in real time and in situ which had made OCT a powerful diagnostic and research tool.
SpectraScience offers its proprietary WavSTAT Optical Biopsy
System to diagnose tissue health optically by using light.
Optical coherence tomography: an emerging technology for biomedical imaging and optical biopsy
. Neoplasia 2000; 2: 9-25, doi: 10.1038/sj.neo.7900071.
French medical device maker Mauna Kea Technologies has set-up of an optical biopsy
programme at the CHU de Grenoble (university hospital center), the company said on Tuesday.