The dominant emm types of GAS in a given region can be determined through epidemiological investigation, and then safe and opsonic
epitopes on N terminal of M protein of these dominant strains can be selected to compose a multivalent vaccine.
pallidum to evade the immune response limiting the antibodies' cytotoxic and opsonic
capacities (like its homolog in H.
No demonstrable C3b could be identified, but a mixture of opsonic
iC3b and nonopsonic C3d was recovered from the surface of S.
equi infection, while the opsonic
ability of foal serum was found to be a limited factor for phagocytosis from the ages of 1 to 6 weeks [41, 42].
Overall the PEG molecules on the liposome surface do not interfere with production of opsonic
components from the C3 component.
Three sets of conditions were taken, i.e., 50 [micro]l bacterial dilution was mixed with 50 [micro]l heat inactivated normal serum (NS) and/or convalescent serum (CS) and 400 [micro]l of non opsonic
heparinized donor blood, as a source of neutrophils and complement.
It is also known to be opsonic
in nature and activates the complement system and phagocytes.
An impaired opsonic
activity of antibodies has been reported in multigravid women coinfected with HIV and malaria as in comparison to those without HIV.
Also, a reported case of an adult SSSS, in which a patient presented normal opsonic
activity and phagocytic function but marked defects in neutrophil chemotaxis and T-lymphocyte function (13), reinforces the importance of immune response in disease pathogenesis.
The MBL gene [MBL2, mannose-binding lectin (protein C) 2, soluble (opsonic
defect)] harbors several common polymorphisms that affect the concentration or function of the protein (3).
This concurs with the report of Cline and Lehrer who indicated that the opsonic
property of Candida immune serum was attributed to the presence of specific IgG, and not to activation of the complement system.