The dominant emm types of GAS in a given region can be determined through epidemiological investigation, and then safe and
opsonic epitopes on N terminal of M protein of these dominant strains can be selected to compose a multivalent vaccine.
pallidum to evade the immune response limiting the antibodies' cytotoxic and
opsonic capacities (like its homolog in H.
No demonstrable C3b could be identified, but a mixture of
opsonic iC3b and nonopsonic C3d was recovered from the surface of S.
equi infection, while the
opsonic ability of foal serum was found to be a limited factor for phagocytosis from the ages of 1 to 6 weeks [41, 42].
Overall the PEG molecules on the liposome surface do not interfere with production of
opsonic components from the C3 component.
Three sets of conditions were taken, i.e., 50 [micro]l bacterial dilution was mixed with 50 [micro]l heat inactivated normal serum (NS) and/or convalescent serum (CS) and 400 [micro]l of non
opsonic heparinized donor blood, as a source of neutrophils and complement.
It is also known to be
opsonic in nature and activates the complement system and phagocytes.
An impaired
opsonic activity of antibodies has been reported in multigravid women coinfected with HIV and malaria as in comparison to those without HIV.
Also, a reported case of an adult SSSS, in which a patient presented normal
opsonic activity and phagocytic function but marked defects in neutrophil chemotaxis and T-lymphocyte function (13), reinforces the importance of immune response in disease pathogenesis.
The MBL gene [MBL2, mannose-binding lectin (protein C) 2, soluble (
opsonic defect)] harbors several common polymorphisms that affect the concentration or function of the protein (3).
This concurs with the report of Cline and Lehrer who indicated that the
opsonic property of Candida immune serum was attributed to the presence of specific IgG, and not to activation of the complement system.
