(4) Other presenting symptoms include abdominal discomfort and distension, bone pain, watery diarrhea, periorbital ecchymoses due to orbital metastases, subcutaneous skin nodules, and opsoclonus-myoclonus
The anti-Purkinje antibody, otherwise known as antiYo, has been associated with paraneoplastic cerebellar degeneration (PCD) and two other syndromes, paraneoplastic sensory peripheral neuropathy and the opsoclonus-myoclonus
Autoantigen diversity in the opsoclonus-myoclonus
Ganglioneuroblastoma, intermixed with opsoclonus-myoclonus
VAERS data show that Gardasil has been associated with 24,184 adverse effects since its debut in June 2006, including seizures, anaphylaxis, paralysis, transverse myelitis, Lou Gehrig's disease (ALS), acute disseminated encephalomyelitis (ADEM), opsoclonus-myoclonus
syndrome (uncontrollable movement of the eyes back and forth and jerking movements of the extremities), brachial neuritis, loss of vision, postural tachycardia syndrome, facial palsy, deep vein thrombosis, pulmonary embolism, chronic fatigue syndrome, blindness, pancreatitis, speech problems, short-term memory loss, miscarriage, multiple sclerosis, autoimmune disorders, Guillain-Barre syndrome, abnormal Pap smears, and even cervical cancer.
syndrome (OMS) is characterized by rapid, involuntary multivectorial eye movements without intersaccadic intervals.
Patients may present with abdominal distention, malaise, weight loss, Horner Syndrome and Opsoclonus-Myoclonus
. Two-third of the patients may have metastatic bone disease at presentation, when this manifests as limping & irritability, it is known as Hutchinson Syndrome.
Location of paraneoplastic neurological syndrome and subtypes described Brain Limbic encephalitis Brainstem encephalitis Cerebellar degeneration Opsoclonus-myoclonus
Visual syndromes--cancer-associated retinopathy, optic neuritis Extrapyramidal syndromes--chorea, parkinsonism Spinal cord Necrotising myelopathy Inflammatory myelitis Motor neuron dise ase Stiff person syndrome Subacute motor neuropathy Dorsal root Sensory neuropathy ganglion Peripheral Autonomic neuropathy nerve Acute sensorimotor neuropathy, e.g.
Central nervous system Limbic encephalitis Encephalomyelitis Brainstem encephalitis Stiff-person syndrome Opsoclonus-myoclonus
Subacute cerebellar degeneration Paraneoplastic visual syndromes Cancer-associated retinopathy Melanoma-associated retinopathy Paraneoplastic optic neuropathy Motor neuron syndromes Subacute motor neuronopathy Other motor neuron syndromes Peripheral nervous system Acute sensorimotor neuropathy Subacute sensory neuronopathy Chronic sensorimotor neuropathy Subacute autonomic neuropathy Paraneoplastic peripheral nerve vasculitis Neuromuscular junction and muscle Myasthenia gravis Lambert-Eaton syndrome Polymyositis/dermatomyositis Acute necrotizing myopathy Cachectic myopathy Neuromyotonia TABLE 2: Diagnostic criteria of paraneoplastic limbic encephalitis.
Detection of EV71 as the single most prevalent EV type associated with NP-AFP is of clinical significance because it is regarded as the most virulent neurotropic EV, next to poliovirus, associated with poliomyelitis-like paralytic disease, meningitis, meningoencephalomyelitis, Guillain-Barre syndrome, transeverse myelitis, cerebellar ataxia, opsoclonus-myoclonus
syndrome, benign intracranial hypertension, brainstem encephalitis (34-36), and frequent epidemics of hand, foot, and mouth disease with substantial illness and death worldwide affecting >500,000 children in the Asia-Pacific region and causing >200 deaths in China during the past decade (37-39).
Neurological IRIS manifests in a variety of ways, including acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and, more rarely, opsoclonus-myoclonus
. Management may include specific antimicrobial agents and corticosteroids.