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recombinant interleukin-11, used as a stimulator of hematopoiesis to prevent thrombocytopenia following myelosuppressive chemotherapy.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
IL11A gene on chromosome 19q13.3-q13.4 that encodes interleukin-11, a member of the gp130 family of cytokines, which drive the assembly of multi-subunit receptor complexes, all of which contain at least one molecule of the transmembrane signalling receptor IL6ST. IL11 directly stimulates the proliferation of haematopoietic stem cells and megakaryocyte progenitor cells, and it induces megakaryocyte maturation resulting in increased platelet production.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.