opioid receptors

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Related to opioid receptors: Opioid Analgesics

Opioid receptors

Receptors located in the brain and various organs that bind opiates or opioid substances.
Mentioned in: Methadone

opioid receptors,

n.pl any of the several receptors to which opiates bind. Classified into three groups delta, kappa, and mu based on the specific substances they bind and the resulting physiologic effects.


1. any synthetic narcotic that has opiate-like activities but is not derived from opium.
2. denoting naturally occurring peptides, e.g. enkephalins, that exert opiate-like effects by interacting with opiate receptors of cell membranes.

endogenous opioid
opioid receptors
specific receptor sites for opioids, named for the drugs which have a high binding affinity for them. The main ones are mu (morphine), kappa (opioid agonist-antagonists such as pentazocine) and delta (enkephalin endogenous opioids). Subtypes exist and others, such as sigma and epsilon, have been identified.
References in periodicals archive ?
Now working their way through the developmental pipeline are two promising novel classes of drugs designed to target the physiologic mechanisms underlying this common and challenging problem: neurokinin 1 (NK1) receptor antagonists and selective opioid receptor agonists, explained Dr.
Endorphins naturally block pain by binding to opioid receptors in the spinal cord and other parts of the nervous system.
In a test tube, the scientists melded the light-sensing protein rhodopsin to key parts of opioid receptors to activate receptor pathways using light.
Likewise, TRPV1 receptors may also change the expression of opioid receptors.
Therefore the present study was conducted to find out if lesion of septum decreases food intake and also to find out if this lesion alters hypophagia induced by opioid antagonist naloxone which may normally act through septal opioid receptors along with through the opioid receptors in other areas of CNS.
Stevens of TSRI's Department of Integrative Structural and Computational Biology, said that this discovery has helped them decipher a 40-year-old mystery about sodium's control of opioid receptors.
Opioid receptors can be found within the central nervous system (CNS) as well as throughout the peripheral tissues, and they are normally stimulated by endogenous peptides (endorphins, enkephalins, and dynorphins) produced in response to noxious stimulation.
Many of today's most powerful painkillers work by activating one of these proteins, the mu opioid receptor.
Because opioid receptors differ, "you can get enhanced analgesia with using overall less morphine equivalents, or you could get fewer side effects with the same level of analgesia, when you combine two different opioids.
Direct preconditioning of cardiac myocytes via opioid receptors and KATP channels Circ Res 1999; 84:1396-1400.