Naloxone, an opioid receptor
antagonist, quickly and powerfully reverses the effect of opioids and is particularly effective at reversing respiratory depression.
By combining the rhodopsin protein, which senses light in the eye's retina, with a specific type of opioid receptor
called a Mu opioid receptor
, the researchers were able to build a receptor that responds to light in exactly the same way that standard opioid receptors
respond to pain-killing drugs.
Nalmefene, an opioid receptor
antagonist, received marketing approval across Europe for use specifically in a novel as-needed dosing regimen that is under the patient's control.
8 Angstroms (180 trillionths of a meter)-the sharpest picture yet of an opioid receptor
There are multiple opioid receptor
subtypes named using the first letter of the first ligand that was found to bind to them: [mu] (MOP, for morphine); [kappa] (KOP, for ketocyclazocine); 8 (DOP), named after the mouse vas deferens tissue in which the receptor was first characterized.
Many of today's most powerful painkillers work by activating one of these proteins, the mu opioid receptor
Scientists are now one step closer to developing anti-addiction medications, thanks to new research that provides a better understanding of the properties of the only member of the opioid receptor
family whose activation counteracts the rewarding effects of addictive drugs.
Effects of drugs interacting with opioid receptors
during normal perfusion or ischemia and reperfusion in the isolated rat heart--an attempt to identify cardiac opioid receptor
subtype(s) involved in arrhythmogenesis.
Furthermore, the different receptor types of interact, such that pharmacological action at one opioid receptor
type may modify the biochemical and /or functional properties of another [7,16,19].
The study further suggests that kappa-mu opioid receptor
heterodimers could function as a molecular switch that shifts the action of kappa-opioid receptors
and endogenous chemicals that act on them from pain promoting to pain alleviating.
We were quite excited to find that our results supported that naltrexone was specifically effective in women and in people who carried a gene related to the brain's natural morphine system called the mu opioid receptor
gene (OPRM1)," he said.
the leader in the discovery of G-protein coupled receptor (GPCR) biased ligands, announced today that it has been awarded by the National Institutes of Health a five year U01 cooperative agreement, to develop a novel biased ligand to the delta opioid receptor
for major depressive disorder.