opioid peptide


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opioid peptide

Endogenous opiate Any natural polypeptide neurotransmitters involved in perception of pain, response to stress, regulation of appetite, sleep, memory, learning
References in periodicals archive ?
Among the neurotransmitters that affect the release of gonadal secretions are endogenous opioid peptides like enkephalin, dynorphin, beta endorphins etc.
The pharmacophore of the opioid peptides, generally the four N-terminal residues Tyr1-Gly2-Gly3-Phe4, is the 'message' responsible for the opioid activities (170) while the remainder of the sequence, or 'address', is responsible for receptor recognition (171).
The interactions between leukocyte-derived opioid peptides and peripheral nociceptor endings carrying opioid receptors (24,25) may explain the connection of the pathophysiologic common basis of all the examined variables in our study with the pain mechanisms.
The opioid peptides are some of the most widely known neuropeptides.
Endogenous opioid peptides are involved in CNS functions from development to immune modulation (52-53).
Endogenous opioid peptides have a well-defined role in neuroendocrine system, given that regulate the activity of gonadotropin releasing neurons (GnRH) and consequently secretion of follicle stimulating hormone (FSH), luteinizing hormone (LH), gonadal steroid production and sexual behavior (RUSSELL et al.
Pharmacological studies (Gianoulakis 2004; Oswald and Wand 2004) using subtype-specific antagonists show that the key element in opioid peptide systems involved in the positive reinforcing effects of alcohol is the [mu]-opioid receptor.
Scientific evidence suggests that increased opioid peptide transmission in the basal ganglia might underlie dyskinesia after chronic l-DOPA treatment and that opioid antagonists might be useful as adjuncts to l-DOPA therapy for Parkinson's disease.
Bryan Fry, a researcher from the University of Queensland, Australia, said in a statement Thursday: "The fish injects other fish with opioid peptides that act like heroin or morphine, inhibiting pain rather than causing it.
During childhood, the LHRH surge is repressed through inhibitory signals in the hypothalamus mediated by [gamma]-aminobutyric acid and opioid peptides (Terasawa and Fernandez 2001).
Opioid activation leads to the processing of opioid peptides from their precursor, proenkephalin and the simultaneous release of antibacterial peptides contained within the precursor as well.