opioid antagonist


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Related to opioid antagonist: naloxone, Opioid Agonist

o·pi·oid an·tag·o·nist

(ō'pē-oyd an-tag'ŏ-nist)
Examples include naloxone and naltrexone that have high affinity for opiate receptors but do not activate these receptors. These drugs block the effects of exogenously administered opioids (e.g., morphine, heroin, meperidine, and methadone), or of endogenously released endorphins and enkephalins.
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References in periodicals archive ?
As a full opioid antagonist, XR-NTX can precipitate severe withdrawal, so patients need to be completely detoxified before starting XR-NTX, in contrast to BUP-NX, which patients can start even while still in mild withdrawal.
Injectable extended-release naltrexone for opioid dependence: 3 studies
Naltrexone, another opioid antagonist, is similar to naloxone in that it does not exclusively go to peripheral mu receptors.
Recognizing and Treating Opioid-Induced Constipation in Chronically Ill Children
(31) Opioid antagonists modified to prevent entry into the CNS (eg methylnaltrexone, naloxegol) are second-line remedies.
Understanding opioids
(2,3) Preliminary data suggest that treatment with an opioid antagonist also reduces overdose.
Policies and Resolutions
Another strategy employs an opioid antagonist that interferes with, reduces or defeats the euphoria associated with abuse.
The opioid abuse epidemic
It's an opioid antagonist, so it blocks the euphoria that you might get when you are using a drug of abuse such as an opioid."
Opioids: addiction is a different beast' in kids: this is the second segment of a two-part series on opioid addiction in adolescent
Cases with a history consistent with an opioid overdose that respond to an opioid antagonist but with no traditional opioids detected in the toxicological analysis should be subjected to further investigation for a novel compound.
Commentary
The implant delivers non-addictive medication Naltrexone, an opioid antagonist that can significantly reduce cravings for opioids and alcohol.
BioCorRx (BICX) Update: BICX101 Development Continues to Progress
Distribution of the opioid antagonist, Narcan[R], L.
Has the federal government declared war on chronic pain patients?
Allows a person or organization acting under a standing order to store and distribute an opioid antagonist, provided they did not request or receive compensation.
Legislative summary: 84th Texas Legislative Session
Approximately 95% of the naltrexone absorbed is metabolized and converted in its principal active metabolite, 6-beta-naltrexol, a pure opioid antagonist with a longer half life than naltrexone (12.9 hours), which facilitates its longer lasting action.
Opioid Receptor Antagonists in the Treatment of Alcoholism/Los Antagonistas de los Receptores Opioides en el Tratamiento del Alcoholismo

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