ophthalmic solution


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solution

 [so-loo´shun]
1. a homogeneous mixture of one or more substances (solutes) dispersed molecularly in a sufficient quantity of dissolving medium (solvent).
2. in pharmacology, a liquid preparation of one or more soluble chemical substances, which are usually dissolved in water. For names of specific solutions, see under the name.
3. the process of dissolving or disrupting.
4. a loosening or separation.

Preparation of Solutions. Formula for preparing solutions from a pure drug:


For example, to prepare 2000 mL of a 2 per cent solution from boric acid crystals, the proportion would be

Formula for preparing solutions from stock solutions:

For example, to prepare 1000 mL of a 2 per cent solution from a 4 per cent stock solution, the proportion would be
aqueous solution one in which water is used as the solvent.
BCG solution an aqueous suspension of bacille Calmette-Guérin for instillation into the bladder to activate the immune system in treatment of superficial bladder cancers. It reduces the risk of a subsequent bladder cancer developing, although the exact mechanism of action is unknown.
buffer solution one that resists appreciable change in its hydrogen ion concentration (pH) when acid or alkali is added to it.
colloid solution (colloidal solution) imprecise term for colloid (def. 3).
hyperbaric solution one having a greater specific gravity than a standard of reference.
hypertonic solution one having an osmotic pressure greater than that of a standard of reference.
hypobaric solution one having a specific gravity less than that of a standard of reference.
hypotonic solution one having an osmotic pressure less than that of a standard of reference.
isobaric solution a solution having the same specific gravity as a standard of reference.
isotonic solution one having an osmotic pressure the same as that of a standard of reference.
molar solution a solution in which each liter contains 1 mole of the dissolved substance; designated 1 M. The concentration of other solutions may be expressed in relation to that of molar solutions as tenth-molar (0.1 M), etc.
normal solution a solution in which each liter contains 1 equivalent weight of the dissolved substance; designated 1 N.
ophthalmic solution a sterile solution, free from foreign particles, for instillation into the eye.
saturated solution one in which the solvent has taken up all of the dissolved substance that it can hold in solution.
sclerosing solution one containing an irritant substance (sclerosing agent) that will cause obliteration of a space, as in sclerotherapy.
standard solution one that contains in each liter a definitely stated amount of reagent; usually expressed in terms of normality (equivalent weights of solute per liter of solution) or molarity (moles of solute per liter of solution).
supersaturated solution an unstable solution containing more of the solute than it can permanently hold.
volumetric solution one that contains a specific quantity of solvent per stated unit of volume.

oph·thal·mic so·lu·tion

(of-thal'mik sŏ-lū'shŭn)
Sterile solution, free from foreign particles and suitably compounded and dispensed for instillation into the eye.
References in periodicals archive ?
Dorzolamide Hydrochloride Ophthalmic Solution USP, 2% has an estimated market size of US$ 35 million for twelve months ending December 2018 according to IQVIA.
Many studies have compared 0.1% olopatadine administered twice a day; but in our study, we used recently recommended 0.2% ophthalmic solution of olopatadine which can be administered once daily as it improves the patient compliance specifically in children with allergic conjunctivitis.
Target: ANDAs for Ciprofloxacin Ophthalmic Solution 3%, Levofloxacin Ophthalmic Solution 0.5%, and Diclofenac Sodium Ophthalmic Solution 0.1%
Table 1: Tear production in KCS affected dogs treated with Takfa ophthalmic solution. Sr.
Purpose: To report a patient with glaucoma who developed recurrent herpetic keratitis while using two different prostaglandin analogue ophthalmic solutions.
Ciprofloxacin ophthalmic solutions. Ciprofloxacin ophthalmic solution manufactured in Bangladesh (Ciprocin, trade name, manufactured by Square Pharmaceuticals Ltd.) and a commercially available ophthalmic solution manufactured in USA (Ciloxan, trade name, manufactured by Alcon Manufacturing Ltd.
* Administering ophthalmic solutions. To be effective, ophthalmic medications must be instilled into the "pouch" of the lower lid and not onto the eyeball itself.
In approximately 3 months, a total of 215 patients were successfully randomised across four treatment arms: netarsudil ophthalmic solution 0.01%, netarsudil ophthalmic solution 0.02%, netarsudil ophthalmic solution 0.04%, and placebo, all administered once daily in the evening.
Aldeyra Therapeutic announced positive results from the Phase 3 ALLEVIATE Trial of 0.25% and 0.5% reproxalap topical ophthalmic solution in patients with allergic conjunctivitis.
* Fall 2018: Expected commercial launch of ZERVIATE[TM] (cetirizine ophthalmic solution), 0.24% in the United States by partner Eyevance Pharmaceuticals, LLC.
M2 EQUITYBITES-January 4, 2018-Perrigo awarded US FDA's tentative approval for generic Prolensa Ophthalmic Solution 0.07%
have received Food and Drug Administration approval for Vyzulta (latanoprostene bunod ophthalmic solution 0.024%).