open-label


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open-label

(ō′pən-lā′bəl)
adj.
Of or related to a clinical trial in which both the researcher and the participant know whether an administered treatment is an experimental drug or a placebo.
References in periodicals archive ?
In the 299 participants in the open-label extension of IPERGAY, HIV infection occurred at a rate of just 0.
3 percent remission rate, per Partial Mayo score at week 60 of the extension study (reflecting 112 weeks from lead-in study baseline), as assessed in the intent-to-treat patients who enrolled in the open-label study extension.
He and his colleagues searched several major databases to identify randomized trials of lipid-lowering therapies that also contained an analysis of patient outcomes after the randomized portion of the trials had ended and an open-label phase had begun.
Several markers of disease progression were followed throughout the open-label extension clinical trial, including the ALSFRS-R, vital capacity, total body weight and body mass index (a measure of obesity).
After an initial 24-week blinded phase of the study, 169 patients received 25 mg of etanercept (Enbrel) twice weekly for an additional 48 weeks during the open-label extension phase.
Sixty-five percent of the 318 children enrolled in the open-label extension completed that portion of the study.
A randomized, controlled open-label study of revision of antiretroviral regimens containing stavudine (d4T) and/or a protease inhibitor (PI) to zidovudine (ZVD)/lamivudine(3TC)/Abacavir (ABC) to prevent or reverse lipoatrophy: 48-week data.
Analyses of data from two subgroups of patients, those who have undergone prior deep brain stimulation (DBS) treatment and those who switched from amantadine immediate-release (IR) to open-label ADS-5102, both showed a rapid and sustained reduction in dyskinesia and OFF after introduction of ADS-5102.
Based on the April data from the company's open-label, randomised, phase 2 study assessing the therapeutic combination of intravenously-administered REOLYSIN given in combination with the chemotherapy agent paclitaxel versus paclitaxel alone in patients with advanced or metastatic breast cancer (IND 213), the combined treatment demonstrated a statistically significant increase in median overall survival.
SAN DIEGO--Rheumatoid arthritis patients who switched from conventional immediate-release prednisone to delayed-release prednisone taken at bedtime experienced a mean reduction of more than 60 minutes in daily morning stiffness that was maintained throughout a 9-month open-label study.
and Genzyme General have announced detailed results from the six-month double-blind Phase 3 clinical trial of Aldurazyme(TM) (laronidase) and preliminary six-month findings from the trial's ongoing open-label extension study.