open-label


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open-label

(ō′pən-lā′bəl)
adj.
Of or related to a clinical trial in which both the researcher and the participant know whether an administered treatment is an experimental drug or a placebo.
References in periodicals archive ?
The researchers found that for the 21 lymphedema patients enrolled in the open-label trial, histopathology and skin thickness significantly improved at four months versus baseline.
Last month, his group published a review of previous research that has compared the effects of giving patients open-label placebos with no treatment.
In the 299 participants in the open-label extension of IPERGAY, HIV infection occurred at a rate of just 0.19% per year during 515 person-years of prospective follow-up, translating to a 97% reduction in risk, compared with the placebo-treated controls in the parent study.
Based on the World Health Organization bleeding scale, the percentage of patients who experienced grade 1-4 bleeding events fell from 63% at the start of the open-label period to 24% at the end, and clinically significant (grade 2-4) bleeding events dropped from 20% to 6%.
.A 55.3 percent remission rate, per Partial Mayo score at week 60 of the extension study (reflecting 112 weeks from lead-in study baseline), as assessed in the intent-to-treat patients who enrolled in the open-label study extension.
The latest trial was launched at the request of ex-HART patients wishing to continue treatment with the drug on an open-label basis, Neurosearch said.
Aware of the critical need for antidepression treatments that might not carry the risk of precipitating a manic episode in bipolar patients, we decided to conduct an open-label add-on trial of eicosapentaenoic acid (EPA) in bipolar depression.
The second study will be a multicenter, randomized, open-label, safety and efficacy clinical trial with a planned enrollment of approximately 300 dialysis or peritoneal patients.
CHICAGO -- An off-the-market antihistamine, previously shown to slow cognitive decline over 1 year in Alzheimer's patients, continued to preserve cognition and memory in a 6-month open-label extension trial.
Nine children (aged eight to 16 years) with attention deficit hyperactivity disorder (ADHD) received, in open-label fashion, an omega-3 fatty acid supplement for eight weeks.