reading frame

(redirected from open reading frame (ORF))
Also found in: Dictionary, Encyclopedia.

read·ing frame

(rēd'ing frām),
The grouping of nucleotides by threes into codons. See: frameshift mutation.

reading frame

n.
One of the three possible ways in which an mRNA sequence of nucleotides can be read as a series of base triplets to specify the amino acids in a protein chain.

reading frame

An imaginary window through which base pairs can be inspected three at a time, and which provides a way in which a nucleotide sequence can be viewed as three different sets of CODONs only one of which is correct.