ookinete


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ookinete

 [o″o-kĭ-nēt´]
the fertilized form of the malarial parasite in a mosquito's body, formed by fertilization of a macrogamete by a microgamete and developing into an oocyst.

o·o·ki·nete

(ō'ō-ki'nēt, -kī'net'),
The motile zygote of the malarial organism that penetrates the mosquito stomach to form an oocyst under the outer gut lining; the contents of the oocyst subsequently divide to produce numerous sporozoites.
Synonym(s): vermicule (2)
[G. ōon, egg, + kinētos, motile]

o·o·ki·nete

(ō'ŏ-kī'nēt)
The motile zygote of the malarial organism that penetrates the mosquito stomach to form an oocyst under the outer gut lining; the contents of the oocyst subsequently divide to produce numerous sporozoites.
[G. ōon, egg, + kinētos, motile]

ookinete

The highly motile fertilized form of the malarial parasite that bores through the lining of the mosquito's stomach to form the OOCYST.
References in periodicals archive ?
It forms leucine-rich repeat protein 1 (LRIM1)/anopheles plasmodium-responsive leucine-rich repeat protein (APL) 1/TEP1cut complex and gets accumulated on the ookinete surface for killing.
PfENO is an interesting transmission-blocking candidate present on the parasite ookinete surface and assists in ookinete invasion of midgut epithelium by recruiting human serine plasminogen through a lysine motif (277-Ala-Lys-Ser-Leu-Val-Lys-282) [74].
Jacalin (a lectin) inhibits ookinete attachment by masking glycan ligands on midgut epithelial surface glycoprotein's.
Plasmodium vivax ookinete surface protein Pvs25 linked to cholera toxin B subunit induces potent transmission-blocking immunity by intranasal as well as subcutaneous immunization.
During the ookinete life stage, the parasite links to these receptors as it migrates to the salivary glands.
Successful development includes exflagellation, fertilization, ookinete formation, and penetration through the peritrophic matrix and midgut epithelium to form oocysts.
Ookinete destruction within the mosquito midgut lumen explains Anopheles albimanus refractoriness to Plasmodium falciparum (3D7A) oocyst infection.
vivax MSP1 fragments (Pv200L); the parasite ligand that contains the receptor-binding domain for Duffy binding protein (DBP-RII); the apical membrane antigen 1 (AMA-1); the ookinete surface antigens (Pvs25 and Pvs28) candidate to transmission blocking vaccines; and several other genes from the asexual blood stages (e.g., MSP3, MSP4, MSP5, MSP9, and the reticulocyte binding protein) that have been identified and partially characterized [17,18, 21].
Two types of Plasmodium ovale defined by SSU rRNA have distinct sequences for ookinete surface proteins.
vivax also has O-type genes, which are expressed during ookinete and oocyst development.
falciparum in anophelines by altering kinetics of ookinete maturation.
More recently, two types of sequences have been characterized for the ookinete surface protein genes, Pos 25, Pos 28-1, and Pos 28-2 in P.