In female mice, expression of LIN28B decreases in the ovary prior to the onset of puberty
, and neither let-7a nor let-7g levels significantly changed .
Excessive nutrition and obesity are thought to trigger the onset of puberty
. Nutritional status during childhood is thought to be 25% responsible for the early onset of puberty
Pubertal height gain and AH were analysed in children who started GH around the onset of puberty
and compared with the outcomes in short SGA children who initiated GH therapy at least one year before the onset of puberty
In fact, the onset of puberty
is a complex phenomenon, which is known to be controlled by genetic, environmental and endogenous factors (Burns et al., 2010).
The age at onset of puberty
was categorised as precocious (<8 years), normal (8-13 years) or delayed (>13 years).
investigated the association between age at onset of puberty
and age at onset of schizophrenia and found a significant negative correlation between the three measurements (first strange behavior, first psychotic symptoms and first hospitalization for psychiatric reasons), which is consistent with the findings in our study (27) However, a study carried out by Ruiz et al.
The association between childhood overweight and early onset of puberty
has been evaluated in several studies, because excess adiposity and body fat are hypothesized to be causal factors of early pubertal development [1-3].
Researchers first noticed the earlier onset of puberty
in the late 1990s, and recent studies confirm the mysterious public health trend.
There are presently around 27,000 research reports on this subject that highlight their connection with cancers, early onset of puberty
, declining fertility and so on.
"If you basically say that the onset of puberty
has a bell-shaped distribution, it seems to many of us the whole curve is shifting to the left," says Paul Kaplowitz, chief of the division of endocrinology and diabetes at Children's National Medical Center in Washington, D.C.
During childhood, migraine prevalence is similar among boys and girls, but with onset of puberty
, the prevalence of migraine increases significantly in women 5-20 per cent and 2-10 per cent in men.
Other factors such as ethnicity, nutritional conditions, and secular trends have been proven to influence the physiological range in age at the onset of puberty
.5 Changes at the time of puberty have implications for the treatment of individual children for diseases later in life, and for chemical testing and risk evaluation for the overall population.