RAV12 binds with high affinity to RAAG12 and exhibits cytotoxic activity in vitro, via an oncotic
cell death mechanism, toward RAAG12-expressing human gastrointestinal tumor cell lines.
The effect of the reduction of colloid oncotic
pressure, with and without reduction of osmolality, on post-traumatic cerebral edema.
surface area, permeability, and oncotic
and hydrostatic pressure gradients across the capillary walls) (30).
The artificial cells were rapidly removed from circulation and they give unfavourable oncotic
pressure levels crucial for efficient [O.
The hetastarch component creates oncotic
pressure, which would normally be provided by blood proteins, and permits retention of intravascular fluid.
The reasons given for this change were to increase the plasma oncotic
pressure in an attempt to decrease cerebral oedema.
7) A normal blood albumin level is necessary to maintain the correct oncotic
pressure and prevent edema.
The role of low intravascular oncotic
pressure as a cause of outward fluid movement has been overstated, as experimental models and most patients with nephrotic syndrome do not show a decreased transcapillary osmotic gradient.
Low serum protein and albumin among newborns is of concern as it will lead to reduced oncotic
pressure and carrier proteins.
Preclinical studies have demonstrated that RAV12 may kill tumor cells in a number of ways: first, the antibody is directly cytotoxic to a human colon cancer cell line in vitro through induction of oncotic
cell death, a form of cell death characterized by cell and organelle swelling and loss of membrane integrity; second, the antibody mediates antibody-dependent cellular cytotoxicity; third, the antibody mediates complement dependent cell killing; and finally, the antibody alters cellular signaling required for cell survival.
necrosis and caspase-dependent apoptosis during galactosamine-induced liver injury in rats.
Pathophysiologically, pulmonary edema results from a rise in the pulmonary capillary hydrostatic pressure, altered capillary permeability, a decrease in oncotic
pressure or lymphatic insufficiency.