According to the company, JX-970 is an
oncolytic virus that is derived from a Western Reserve strain vaccinia virus and its tumor selectivity has been optimized through deletion of thymidine kinase (TK) and vaccinia growth factor (VGF).
New report package "Immunotherapy with
Oncolytic Viruses and mRNA Vaccines & Therapeutics" (available at http://bit.
Transgene previously reported a preclinical proof-of-concept data showing that an
oncolytic Vaccinia virus encoding a sequence of anti-PD1 demonstrated better overall survival than the combination of separate single agents.
Evidence suggests that the host immune response seems to reduce the effectiveness of
oncolytic virotherapy.
Gene therapy progress and prospects cancer:
oncolytic viruses.
The use of
oncolytic viruses to treat cancer dates back as far as the 19th century although unbeknownst to doctors at the time.
Based on a modified herpes simplex virus type T-VEC is an
oncolytic virus designed to replicate in and lyse tumor cells while promoting an antitimor immune response.
These may include novel platform technologies to address so far undrugable targets, new generation vaccines and/or new biological entities, such as
oncolytic virotherapy.
This trial was conducted to evaluate single and repeated intratumoral injections of the
oncolytic virus, HF10.
Cancer-killing or
oncolytic viruses have been used in numerous phase 1 and 2 clinical trials for brain tumors but with limited success.
Shah and his team turned to mesenchymal stem cells (MSCs)--a type stem cell that gives rise to bone marrow tissue--which have been very attractive drug delivery vehicles because they trigger a minimal immune response and can be utilized to carry
oncolytic viruses.
MCT-485 is a very small noncoding double stranded RNA (dsRNA) molecule which has demonstrated a unique cytotoxic,
oncolytic, and immune stimulating activity in in vitro models of hepatocellular carcinoma.
