oncolysis


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oncolysis

 [ong-kol´ĭ-sis]
destruction or dissolution of tumor cells. adj., adj oncolyt´ic.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

on·col·y·sis

(ong-kol'i-sis), Avoid mispronunciation oncoly'sis. Do not confuse this word with onycholysis.
Destruction of a neoplasm; sometimes used with reference to the reduction of any swelling or mass.
[onco- + G. lysis, dissolution]
Farlex Partner Medical Dictionary © Farlex 2012

on·col·y·sis

(ong-kol'i-sis)
Destruction of a neoplasm; sometimes used with reference to the reduction of any swelling or mass.
[onco- + G. lysis, dissolution]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

oncolysis

Destruction or breakdown of a tumour, either spontaneously or as a result of treatment.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Induction of viral, 7-methylguanosine cap-independent translation and oncolysis by mitogen-activated protein kinase-interacting kinase-mediated effects on the serine/arginine-rich protein kinase.
Hepatic arterial infusion (HAI) of rVSV-[beta]-gal into Buffalo rats bearing orthotopically implanted multifocal HCC showed efficient viral transduction, tumor-selective viral replication, and extensive oncolysis. There were no significant vector-associated toxicities and damage to the hepatic parenchyma reported, whereas prolonged survival was reported in vector-treated group [86].
Mossman, "Immunogenic HSV-mediated Oncolysis shapes the antitumor immune response and contributes to therapeutic efficacy," Molecular Therapy, vol.
However, one must note that complete oncolysis was only seen in three patients and as the trial has been published quite recently, there has been little time to evidence any side effects or relapses34.
After activation, macrophages can inhibit the growth and transferring of tumor cells and may have stronger immune functions of endocellular sterilization, exocellular oncolysis, phagocytosis and pinocytosis.
IHC analysis has shown that in addition to inducing tumor cell death directly by cytolysis, oncolysis was also mediated by triggering apoptosis.
Oncolytic viruses are also promising cancer treatments; this virotherapy, in combination with a CXCR4 antagonist, has increased efficacy over oncolysis alone in a triple-negative breast carcinoma syngeneic mouse model; systemic delivery of the armed virus after resection of the primary tumor inhibits the development of metastasis and increases overall tumor-free survival [56].
The oncolysis induced by PA via apoptosis was exhibited clearly the involvement of Bax and Bcl2 both at protein level and gene level.
based on the mechanism by which oncolysis is achieved, NDV has been classified as lytic or non lytic strains for mammalian cells.
Oncolytic viruses replicate in cancer cells, which leads to a disruption ("oncolysis") of these cells and tumor regression.