It has been designed to induce the breakdown of cancer cells (oncolysis
) and allow the local production of chemotherapy in the tumor.
Induction of viral, 7-methylguanosine cap-independent translation and oncolysis
by mitogen-activated protein kinase-interacting kinase-mediated effects on the serine/arginine-rich protein kinase.
Hepatic arterial infusion (HAI) of rVSV-[beta]-gal into Buffalo rats bearing orthotopically implanted multifocal HCC showed efficient viral transduction, tumor-selective viral replication, and extensive oncolysis
. There were no significant vector-associated toxicities and damage to the hepatic parenchyma reported, whereas prolonged survival was reported in vector-treated group .
Mossman, "Immunogenic HSV-mediated Oncolysis
shapes the antitumor immune response and contributes to therapeutic efficacy," Molecular Therapy, vol.
However, one must note that complete oncolysis
was only seen in three patients and as the trial has been published quite recently, there has been little time to evidence any side effects or relapses34.
After activation, macrophages can inhibit the growth and transferring of tumor cells and may have stronger immune functions of endocellular sterilization, exocellular oncolysis
, phagocytosis and pinocytosis.
IHC analysis has shown that in addition to inducing tumor cell death directly by cytolysis, oncolysis
was also mediated by triggering apoptosis.
Oncolytic viruses are also promising cancer treatments; this virotherapy, in combination with a CXCR4 antagonist, has increased efficacy over oncolysis
alone in a triple-negative breast carcinoma syngeneic mouse model; systemic delivery of the armed virus after resection of the primary tumor inhibits the development of metastasis and increases overall tumor-free survival .
induced by PA via apoptosis was exhibited clearly the involvement of Bax and Bcl2 both at protein level and gene level.
based on the mechanism by which oncolysis
is achieved, NDV has been classified as lytic or non lytic strains for mammalian cells.
Positron emission tomography of herpes simplex virus 1 oncolysis
. Cancer Res.
Oncolytic viruses replicate in cancer cells, which leads to a disruption ("oncolysis
") of these cells and tumor regression.