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softening of the bones, resulting from impaired mineralization, with excess accumulation of osteoid, caused by a vitamin D deficiency in adults. A similar condition in children is called rickets. The deficiency may be due to lack of exposure to ultraviolet rays, inadequate intake of vitamin D in the diet, or failure to absorb or utilize vitamin D. There is decalcification of the bones, particularly those of the spine, pelvis, and lower extremities. X-ray examination reveals transverse, fracture-like lines in the affected bones and areas of demineralization in the matrix of the bone. As the bones soften they become bent, flattened, or otherwise deformed. Treatment consists of administration of large daily doses of vitamin D and dietary measures to insure adequate calcium and phosphorus intake. adj., adj osteomala´cic.
antacid-induced osteomalacia osteomalacia in which the combination of low dietary phosphorus intake and chronic excessive consumption of aluminum hydroxide–containing antacids has led to phosphate depletion; characteristics include hypophosphatemia, nephrolithiasis, anorexia, muscle weakness, and bone loss.
1. osteomalacia occurring in anticonvulsant rickets of children.
2. anticonvulsant rickets in adults.
hepatic osteomalacia osteomalacia as a complication of cholestatic liver disease, which may lead to severe bone pain and multiple fractures.
oncogenic osteomalacia a type seen in association with usually benign mesenchymal neoplasms. The tumors appear to produce a substance that impairs renal tubular functions and leads to hypophosphatemia. Called also tumor-induced osteomalacia.
puerperal osteomalacia a type resulting from exhaustion of skeletal stores of calcium and phosphorus by repeated pregnancies and lactation.
renal tubular osteomalacia a type resulting from acidosis and hypercalciuria when deficient renal tubular activity has caused inability to produce acid urine or ammonia.
senile osteomalacia softening of bones in old age due to vitamin D deficiency.
tumor-induced osteomalacia oncogenic osteomalacia.
A rare disorder in which low serum phosphorus levels and excessive wasting of phosphorus by the kidneys accompany weakening and softening of bone. The disease is found in patients with cancer and is caused by excessive circulating levels of fibroblast growth factor.Synonym: tumor-induced osteomalacia.
See also: osteomalacia