Titled "Human activities might influence
oncogenic processes in wild animal populations," (https://www.nature.com/articles/s41559-018-0558-7) the paper appeared online Monday in the journal Nature Ecology & Evolution.
Key words:
Oncogenic viruses, Cervical cancer, Hepatocellular carcinoma
The
oncogenic potential of each type of HPV is well described.
Larsson et al., "Fibroblast growth factor 23 in
oncogenic osteomalacia and X-linked hypophosphatemia," New England Journal of Medicine, vol.
This paper shows that incubation at very low-oxygen tensions determines the suppression of driver
oncogenic proteins and signals in a number of leukemia cell populations, leading to hypothesizing that this suppression is a widespread phenomenon occurring in different types of cancers, including solid neoplasias.
Thus the dynamic changes of specific clonal size also might reflect the
oncogenic potentials of specific mutations [11,12].
The cost-benefit associated with the mRNA-based hrHPV assay observed in these analyses arises from the improved specificity of the mRNA-based assay that detects expression of HPV
oncogenic proteins, as opposed to DNA-based testing that reports only presence of the virus.
The interplay between the fused TCF3-HLF
oncogenic protein, additional DNA changes and altered gene expression program leads to a re-programming of leukemic cells to an early, stem-cell like developmental stage, although the phenotypic appearance of the cells remains similar.
Anne Schuchat referred to the expanded coverage of additional
oncogenic HPV types with the 9-valent vaccine as "a milestone." But, she added, "while HPV-related cancer coverage can now expand, other types of coverage present ongoing challenges." She noted that 57% of girls aged 1317 years have received the first dose of HPV vaccine, which could exceed 90% "if teenagers were offered and accepted HPV vaccination every time they received another vaccine." Coverage is included in the Vaccines for Children program and has improved with the Affordable Care Act, although some barriers to access remain, "in practice, if not in statute," she pointed out.
Oncogenic osteomalacia is the most common presentation of this tumour.
DNA was extracted from the tampon specimens and tested for any of the 15 high-risk viral types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, 82), HPV 16 and 18 being the two most
oncogenic. Roughly half of the women took up the screening opportunity, and molecular screening identified cervical cancer risk in 30% and a high risk of future disease in 9.1%.
Chickens may be infected with 3 different
oncogenic viruses: avian leukosis virus (ALY), reticuloendotheliosis virus (REV), and Marek's disease herpesvirus (MDV).
