oncogenes


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oncogenes

Genes that contribute to cancerous changes in cells. Oncogenes are mutations of normal cell genes and must work together to cause cancer. Similar or identical genes are found in viruses known to be able to cause cancer. If one of the three virus genes-gag, pol or env—is replaced by an oncogene, such as ras, the virus becomes capable of causing cancer. The normal ALLELES of the oncogenes are called proto-oncogenes.

oncogenes

1. genes carried by tumor viruses that are directly and solely responsible for the neoplastic transformation of host cells. Many oncogenes function after integration into the DNA of the host cell and some up-regulate normal downstream host cell genes to cause neoplasia.
2. any genetic element linked to cancer.
References in periodicals archive ?
These oncogenes may function like a mechanic who is always on the spot to keep a junk car running," Gilbertson said.
Global Oncogene Inhibitors Market Overview - Oncogene Inhibitors Pipeline by Company, Indication & Phase - Oncogene Inhibitors Pipeline: 185 Drugs - Majority Oncogene Inhibitors in Preclinical Phase: 105 Drugs - Proto Oncogene Protein c met Inhibitors Pipeline: 42 Drugs - Proto Oncogene Protein c-akt Inhibitors: 39 Drugs - Marketed Oncogene Inhibitors: 22 Drugs - Marketed Proto-Oncogene Protein c-bcl-2 Inhibitors: 8 Drugs
4] Genes: let-7; HRAS, v-Ha-ras Harvey rat sarcoma viral oncogene homolog; KRAS, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; NRAS, neuroblastoma RAS viral (v-ras) oncogene homolog; CCND2, cyclin D2; CDK6, cyclin-dependent kinase 6; CDC25, cell division cycle 25 homolog C (S.
He led an international team that discovered that the melanocyte master regulator MITF (microphthalmia-associated transcription factor)--which normally regulates melanocyte differentiation and survival--is also a lineage survival oncogene figuring prominently in metastatic melanoma (Nature 2005; 436:117-22).
14,21-23) We are currently investigating the quantitative differences in the expression of EphB4 with respect to tumor characteristics, induction of EGFRs, inactivation of tumor suppressor genes, and activation of oncogenes.
The oncogene NF-kappaB on the other hand, promotes cell division resulting in the synthesis of substrates for cell division.
Several of these genes endow tumor cells with greater resistance to chemotherapeutic drugs, while others are oncogenes, mutated genes that encourage a cell's proliferation or growth.
Frank Slack for the regulation of oncogenes by microRNA's.
This study uses genetically engineered animals in which different oncogenes can be turned on and off.
Aggressive forms of cancer are often driven by the abnormal over-expression of cancer-promoting genes, also known as oncogenes.
It's even harder to figure out how to switch off such oncogenes.