Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) constitute a conserved family of oncofetal
RNA binding proteins (RBPs) important in embryonic development, and whose expression in tumours is strongly correlated to cancer dissemination.
OA-519 - Opiod Peptides - P-glycoprotein - Pancreatic Oncofetal
Antigen (POA) - Placental Lactogen - PR92 - Proliferative Index, Ki-67 - Px - RB Inactivation/Deletion - Ret - SCCL 175 - Selectin - Sialic Acid - Sialyl SSEA-1/SLX - SN10 - Somatostatin - TA-90 - TABA - Tachykinin - TAG 12 - TPS - Troponin - Tubulin - VCAM - VEGF
This category contains two groups of markers, (i) molecular/ genetic oncofetal
markers that might be expressed by many different types of human neoplasms, much akin to established oncofetal
protein markers (e.
IMP3 is an oncofetal
protein highly expressed in fetal tissue and malignant tumors but rarely found in adult, benign tissues.
AFP is an oncofetal
antigen with an important diagnostic role in primary liver tumours and GCTs.
The fibronectin isoform containing the ED-B oncofetal
domain: a marker of angiogenesis.
The role of the CSF1-RANKL system and that of the liver molecule, oncofetal
fibronectin, a protein that has traditionally been viewed as an extracellular matrix protein are also discussed.
It is the receptor for alpha-fetoprotein and is classified as an oncofetal
antigen due to its presence on both fetal and malignant tissues.
Hepatocellular carcinomas in dogs have been separated from cholangiocarcinomas on the basis of their immunohistochemical staining patterns for oncofetal
antigens in one report .
The company's research is focused on the use of the oncofetal
antigen ("OFA"), or more specifically, iLRP - immature Laminin Receptor Protein, as a cancer immunogen (a cancer target against which the immune system is directed) found in many tumor cell lines or fetal tissue, but not found in normal mature tissue.
Coverage includes salivary biomarkers, tumor markers in pseudopodia for invasive migration, intraocular lymphoma markers, serum tumor markers in breast cancer, diagnostic classification using gene expression profiling in AML, tumor antigens as markers of minimal residual disease in acute myeloid leukemia, activity and expression of dipeptidyl peptidase IV and cathepsin H in human cutaneous melanoma compared to other common cancers, ovarian cancer detection, comparison of the prognostic association of nucleolar size between uveal and conjunctival melanoma, biomarkers of hepatocellular carcinoma, cell adhesive markers in metastasizing colorectal carcinoma, and fetal hemoglobin as an oncofetal
glycoproteins or mucins, oncofetal
proteins, hormones, and so on).