Market Insights According to Quest Diagnostics, CEA is an oncofetal
glycoprotein present in the gastrointestinal tract and body fluids of the embryo and fetus.
A possible driver of neoplastic transformation of maturation-arrested gonocytes is the failure of these cells to downregulate expression of OCT3/4, an antiapoptotic oncofetal
protein, a process that normally occurs when gonocytes relocate from the center of the seminiferous tubule to the spermatogonial niche.
An isoform of fibronectin named oncofetal
fibronectin has been found in high levels in patients with primary biliary cirrhosis and it mediates bone loss by inhibiting bone formation (61).
protein glypican-3 distinguishes yolk sac tumor from clear cell carcinoma of the ovary.
They revealed that the carbohydrate that the malaria parasite attaches itself to--an oncofetal
chondroitin sulfate (CSA)--which is expressed in the placenta is the same as the one displayed on proteoglycans in cancerous cells (the placental and malignant compartments display a common CS signature that binds malarial protein,VAR2CSA,) (Figure 7).
antigens, including alpha fetoprotein (AFP), human chorionic gonadotropin (hCG), carcinoembryonic antigen (CEA), and cancer antigen 125 (CA-125), are elevated during gestation, making them poor markers for malignancy.
Increase of O-glycosylated oncofetal
fibronectin in high glucose-induced epithelial-mesenchymal transition of cultured human epithelial cells," PLoS ONE, vol.
39] initially evaluated miRNAs expression in the serum of 10 patients with HCC and demonstrated that miR-500 is an oncofetal
miRNA which was abundantly expressed in the sera of HCC patients and returned to normal after the surgical treatment.
proteins are antigens that are normally produced during the embryonic development and their production is limited or completely absent/stopped in adults.
Six of the 11 analytes examined (HE4, proGRP, SCC, CEA, CA19-9, and AFP) showed a similar, expected pattern for oncofetal
Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) constitute a conserved family of oncofetal
RNA binding proteins (RBPs) important in embryonic development, and whose expression in tumours is strongly correlated to cancer dissemination.
This category contains two groups of markers, (i) molecular/ genetic oncofetal
markers that might be expressed by many different types of human neoplasms, much akin to established oncofetal
protein markers (e.