Oncternal believes ROR1 is an attractive target for cancer therapy because it is an oncofetal
antigen - a protein not normally expressed in adults, but which confers a survival and fitness advantage when reactivated and expressed by tumor cells.
In another study, lung cancer cells are signified to secrete IL-6 to transport galectin-3-expressing inflammatory myeloid cells into the blood; it follows the interaction of myeloid cells in the metastatic niche, through cell surface expression of an oncofetal
galectin-3 carbohydrate ligand (T antigen) of metastatic cancer cells (50).
"Burkitt Lymphoma Expresses Oncofetal
Chondroitin Sulfate without being a Reservoir for Placental Malaria Sequestration." Int J Cancer 140 1597-1608 on 4/1/2017
Because of the fact that it is primarily expressed by fetal tissues and malignant tumours, it is referred to as an oncofetal
ASN004 is an Antibody Drug Conjugate that targets the 5T4 oncofetal
antigen, which is expressed in a wide range of malignant tumors but has very limited expression in normal tissues.
gene glypican 3 is regulated in the postnatal liver by zinc fingers and homeoboxes 2 and in the regenerating liver by alpha-fetoprotein regular 2.
gene SALL4 in aggressive hepatocellular carcinoma.
It is an oncofetal
antigen, and its serum levels are increased at a rate of 75% in colorectal cancer recurrence.
"The results of this preclinical work with ADXS-HOT represent an exciting opportunity that may allow us to develop disease-specific immunotherapies that have the potential to be effective against multiple targets, capable of generating high-avidity T cells against shared of public mutations, as well as multiple proprietary highly immunogenic cancer-testes and oncofetal
antigens for multiple tumor types," said Robert G.
protein IMP3, a new diagnostic biomarker to distinguish malignant mesothelioma from reactive mesothelial proliferation.
In addition to being an oncofetal
antigen and diagnostic marker for liver cancer, AFP possesses a variety of biological functions, such as transport function similar to the class of albumin family, transporting metal ions, drugs, bilirubin, and steroids [1-4].