The occurrence of oncocytic cells in salivary glands can be categorized as oncocytic metaplasia, nodular or diffuse oncocytosis, and oncocytoma.
Oncocytosis was the accumulation and proliferation of oncocytes in the salivary glands.
A case of acquired renal cystic disease (ACDK) with oncocytosis, a dominant nodule (oncocytoma), multiple adenomas and a microscopic papillary renal cell carcinoma associated with crescentic glomerulonephritis.
Renal oncocytosis and multiple papillary adenomas with oncocytoma as dominant nodule coexisting with papillary carcinoma in a patient with diabetic glomerulosclerosis, acquired renal cystic disease and B cell lymphoma.
In this regard, Brandwein and Huvos (1) found a history of radiation exposure in some of their cases, and Becker et al (14) described an age-dependent intracellular metabolic defect associated with mitochon driopathy as an explanation for the development of oncocytosis in 2 of their cases.
15) The WHO groups these tumors into three distinct categories: diffuse oncocytosis, multifocal nodular oncocytic hyperplasia (MNOH), and oncocytomas (benign and malignant).
In the first large series on hybrid tumors, Tickoo et al (13) reported on a group of patients with renal oncocytosis
, some of whom developed tumors with hybrid morphologies.
1) These tumors are classified as one of three types: diffuse oncocytosis, focal adenomatous oncocvtic hyperplasia, and oncocytoma.
Oncocytomas may be multifocal or bilateral, and as many as 7% of cases may represent diffuse oncocytosis rather than a single mass.
The case reported by Leroy et al (1) describes an association between oncocytosis and renal failure in a patient in whom a papillary renal cell carcinoma was also present.
Bilateral renal oncocytosis with renal failure: immunohistochemical and cytogenetic study of a case associated with a papillary renal cell carcinoma.
We present a new case of oncocytosis
associated with a papillary renal cell carcinoma.