Szumlanski et al., "Olsalazine
and 6-mercaptopurine-related bone marrow suppression: a possible drug-drug interaction," Clinical Pharmacology & Therapeutics, vol.
Antienflamatuar olarak kullanilan 5-ASA preparatlari barsagin ust kisminda emildiginden dolayi, emilinin distal ince barsak ve kolonda olabilmesi icin absorbe olmayan tasiyicilara baglanarak gelistirilmistir (Olsalazine
, mesalamin, balsalazide).
The prodrugs sulfasalazine, olsalazine
and balsalazide rely on colonic bacterial enzymes to metabolize the inactive precursor to the active drug mesalazine.
Two other agents in this class, balsalazide (Colazal) and olsalazine
(Dipentum), are broken down in the colon to 5-ASA.
Three medicines are used for treating an acute attack: Aminosalicylates (such as balsalazide, mesalazine, olsalazine
, sulfasalazine), Corticosteroids (budesonide, hydrocortisone, prednisolone) and Immunosuppressants (azathioprine, ciclosporin, mercaptopurine) Rest is important during an attack to allow healing to take place.
5-Aminosalicylic acids (such as sulfasalazine, mesalazine, and olsalazine
) are used in the treatment of inflammatory bowel disease.
Active UC should be treated initially with systemic aminosalicylate drugs (such as sulfasalazine, olsalazine
, balsalazide, and mesalamine) or with corticosteroids.
In vitro kinetic studies with recombinant human TPMT demonstrated that sulfasalazine, 5-aminosalicylic acid, balsalazide, and olsalazine
(3-5) inhibit the enzyme activity in a noncompetitive manner.