Criteria to make the diagnosis of PCOS were included oligoovulation
or anovulation, clinical or biochemical signs of hyper-androgenism, and polycystic ovaries by Ultrasonography.
The National Institute of Health (NIH) criteria require anovulation (no ovulation) or oligoovulation
(rare ovulation) plus clinical or biochemical signs of hyperandrogenism.
Family A: Proband (IV-2) has irregular menstrual cycle and oligoovulation
. Ultrasonographic examination revealed small size uterus.
Diagnosis of PCOS was done by Rotterdam classification (Rotterdam indicated PCOS to be present if any 2 out of 3 criteria are met: Oligoovulation
and/or anovulation, excess androgen activity [clinical and or biochemical] and polycystic ovaries (by gynecologic ultrasound multiple cysts more than 2 in number of 2-9 mm size]).
who met any two of the three criteria after exclusion of other causes: oligoovulation
and/or anovulation, clinical or biochemical hyperandrogenism, and polycystic ovaries detected by ultrasound .
For a diagnosis of PCOS, two of the following three criteria must be met: oligoovulation
and/or anovulation, clinical or biochemical signs of excess androgen activity, polycystic ovaries on ultrasound (greater than or equal to 12 follicles 2-9 mm in size or the volume is greater than 10 mL).
In brief, the diagnosis of PCOS was made according to the National Institutes of Health (NIH) 1990 criteria : (i) clinical evidence of hyperandrogenism and/or hyperandrogenemia; (ii) oligoovulation
; and (iii) the exclusion of related disorders.
 Anovulation & oligoovulation
resulting in hyperestrinism, cause prolonged stimulation of the endometrial lining and increase the risk of both endometrial hyperplasia and carcinoma.
According to the most widely used diagnostic criteria (Rotterdam Criteria for Diagnosis of PCOS), at least two of the following need to be present to confirm a diagnosis (after excluding other causes): oligoovulation
and/or anovulation (associated with irregular (or cessation of) menstruation), hyperandrogenism (demonstrated clinically by increased body hair, and in more severe cases, hair loss), and polycystic ovaries, with the exclusion of other aetiologies.
The diagnosis of PCOS relied on the presence of clinical and/or biochemical hyperandrogenism, oligoovulation
, and exclusion of secondary etiologies as reported (14).
In women who experience oligoovulation
or anovulation, ovulation induction is typically offered.
Polycystic ovary syndrome (PCOS) is characterized by androgen excess and oligoovulation
. It is the most common cause of infertility in the United States and affects more than 5 million women.