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Formation of oligomers from larger or smaller molecules.
Synonym(s): oligomerisation.
References in periodicals archive ?
3-6) As in the case of TLRs containing LRR domains, NOD1 detects its ligand through its C-terminal LRR and ligand binding to this domain leads to oligomerization of NOD1 accompanied by binding and activation of receptor interacting protein 2 (RIP2), the obligate initiator of NOD1 downstream signaling pathways.
The p53-dependent transcriptional induction of PUMA and the oligomerization of Bax are implicated in the wogonin-induced apoptosis of prostate cancer cells.
Two main orders of sensors exert this function: Toll-like transmembrane receptors (TLR) [17], and NOD cytosolic systems (nucleotide oligomerization domains) [18,19].
30) Although the function of each of the ZF motifs is not known, studies of the eighth ZF motif by Senyuk et al (31) have shown that the eighth ZF motif is an oligomerization domain, and the expression of isolated eighth ZF motif in vivo results in cell death of 32Dc13 by blocking the granulocyte colony-stimulating factor-induced differentiation.
Human nucleotide binding and oligomerization domain (NOD) protein family, with almost 25 members, is responsible for apoptosis and signal transduction.
Various mechanisms (bottom right) mediate this oligomerization and secretion resulting in secretion of HMW, MMW, and LMW forms [47].
In the present study we propose to identify the specific interactions between intracellular signaling pathways, cellular quality control pathways and alpha-synuclein oligomerization in an attempt to generate a unifying hypothesis that brings together known features of GD and PD pathophysiology.
Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions.
Interestingly, it was also described as beneficial in Alzheimer's disease by reducing /1-amyloid oligomerization and cognitive decline, and further prevented glutamate-induced neuronal death in cultured cerebellar granule cells (Frydman-Marom et al.
Noinville, Adsorption on Montmorillonite Prevents Oligomerization of Bt Cry1Aa Toxin, J.
Proteins of the S100 family regulate the oligomerization of p53 tumor suppressor.
Different forms can result from complex processing, including cleavage, glycosylation and oligomerization of the ANGPTL4 protein, which may be inherent to the cell line/type and species (Grootaert et al.