congenital renal hypoplasia in which there is a reduced number of lobes and nephrons, with hypertrophy of the nephrons. adj., adj oligomeganephron´ic.
A condition that may be a subtype of renal hypoplasia, characterized by ↓ nephrons with hypertrophy of remaining nephrons; kidneys are often small, glomeruli are enlarged, as are the tubules, which may become cystic; it is often first identified in early childhood as a cause of polyuria, polydipsia, and growth failure; it is accompanied by a defect in urinary concentration, sodium reabsorption, and acid excretion, often resulting in metabolic acidosis and slow progression to chronic renal failure
A less well-recognised renal condition that usually only manifests in adulthood is oligomeganephronia. It is in fact congenital renal hypoplasia characterised by a reduced number and hypertrophy of nephrons.
I was promptly introduced to the vastness of renal pathology, particularly the arena of rare pediatric diseases, when I reviewed my first consultative case with Dr Bernstein, namely, an example of oligomeganephronia. Naturally, I did not know the correct diagnosis nor was I even aware of the existence of such an entity.