A goodness of fit test was used to test for monogenic inheritance, double recessive epistasis, and oligogenic
or polygenic character in the [F.
Marker-assisted dissection of the oligogenic
anthracnose resistance in the common bean cultivar 'G2333'.
2002), and allele frequency estimation and Hardy-Weinberg equilibrium (HWE) were estimated using Sequential Oligogenic
Linkage Analysis Routines (SOLAR) (Blangero and Almasy 1996).
Whenever, the variance component linkage analysis detected evidence of potential linkage signals in more than one genomic location, we applied the oligogenic
QTL approach: i) a locus with the highest LOD score was incorporated in the variance component model, ii) the genome scan for a second locus was repeated, conditional on the QTL detected in the previous scan.
Charis Thompson: I think that we should move slowly and focus on monogenic and oligogenic
diseases for which there is not already a good somatic treatment first.
basis of isolated gonadotropin-releasing hormone deficiency.
Eye specialists, geneticists, and others from Europe and North America first introduce the genetics of inherited retinal degenerations, including clinical characteristics and current therapies, genes and mutations causing autosomal dominant retinitis pigmentosa, genomic approaches for the discovery of genes mutated in inherited retinal degeneration, genetic modifiers and oligogenic
inheritance, RNA-sequencing, stem cells as tools for studying the genetics of these disorders, and secondary photoreceptor degenerations in systemic disease.
PCOS is probably an oligogenic
or polygenic disorder.
This provides evidence that some cases of familial transposition are caused by mutations in laterality genes and therefore are part of the same disease spectrum of heterotaxy syndrome, and argues for an oligogenic
or complex mode of inheritance in these pedigrees.
Farrall and Holder (19) in their own analysis have shown that the extensive published recurrence risk data, which have been interpreted to be consistent with an MF/T pattern of inheritance, are equally compatible with an oligogenic
model with perhaps as few as four genes.
Because this kind of resistance is controlled by more than one gene, in other words is oligogenic
or polygenic .
Genes that determine gender are of 2-factor oligogenic
and polygenic systems.