Exclusion of coding region mutations in MSX1, PAX9 and AXIN2 in eight patients with severe oligodontia
An evaluation of cumulative prosthetic treatment costs for young adult patients with birth defects included 22 individuals with hypodontia/ oligodontia
. About half of the patients with implant-supported reconstructions experienced no failures or complications over a median observation period of 8 years.
Based on clinical and radiographic examination, diagnosis of ectodermal dysplasia with oligodontia
Mutation of PAX9 is associated with oligodontia
. Nat Genet.
The treatment of patients with severe oligodontia
due to ectodermal dysplasia will differ according to the unique anatomic limitations, dental status, and age of patients.
An intricate control of Wnt signal activity is necessary for normal tooth development, since point change and frameshift mutations may inhibit or stimulate Wnt signaling and may result in severe oligodontia
, sporadic incisor agenesis, and colorectal cancer [Lammi et al., 2004; Pani 2011].
(23) Mutations in PAX9, another transcription factor, cause oligodontia
involving molar teeth.
PAX9, in chromosome 14 (14q21-q13) have been identified in families with oligodontia
of most molars15.
Bergendal, "Prosthetic habilitation of a young patient with hypohidrotic ectodermal dysplasia and oligodontia
: a case report of 20 years of treatment," The International Journal of Prosthodontics, vol.
Carels, "Tooth agenesis patterns and phenotype variation in a cohort of Belgian patients with hypodontia and oligodontia
clustered in 79 families with their pedigrees," European Journal of Orthodontics, vol.
with supplemental maxillary lateral incisor: A case report.