oligodendroglioma


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oligodendroglioma

 [ol″ĭ-go-den″dro-gli-o´mah]
a neoplasm derived from and composed of oligodendroglia.

ol·i·go·den·dro·gli·o·ma

(ol'i-gō-den'drō-glī-ō'mă),
A relatively rare, relatively slow-growing glioma derived from oligodendrocytes that occurs most frequently in the cerebrum of adult humans; the neoplasm is grossly homogeneous, fairly well circumscribed, moderately firm, and somewhat gritty in consistency with interstitial calcification sufficiently dense so as to be detected by x-ray imaging of the skull. Microscopically, an oligodendroglioma is characterized by numerous small, round or ovoid, oligodendroglial cells with small, deeply stained nuclei (rarely observed in mitosis), and palely stained, indistinct cytoplasm; the neoplastic cells are rather uniformly distributed in a sparse, fibrillary stroma with scattered calcific bodies and an often prominent arcuate vasculature; chemoresponsiveness is associated with loss of heterozygosity on chromosome 1p and 19q.
[oligo- + G. dendron, tree, + glia, + -oma]

oligodendroglioma

/ol·i·go·den·dro·gli·o·ma/ (-den″dro-gli-o´mah) a neoplasm derived from and composed of oligodendrocytes in varying stages of differentiation.

oligodendroglioma

[ol′igōden′drōglī·ō′mə] pl. oligodendrogliomas, oligodendrogliomata
Etymology: Gk, oligos + dendron, tree, glia, glue, oma, tumor
an uncommon brain tumor composed of nonneural ectodermal cells that form part of the supporting connective tissue around nerve cells. The lesion, a firm reddish-gray mass with calcified spots and a distinct margin, may be large. The tumor develops most often in frontal, parietal, and paraventricular sites but also may occur in the cerebellum. Also called oligodendroblastoma.

ol·i·go·den·dro·gli·o·ma

(ol'i-gō-den'drō-glī-ō'mă)
A rare, slowly growing glioma derived from oligodendrocytes that occurs most frequently in the cerebrum of adults.
[oligo- + G. dendron, tree, + glia, + -oma]

oligodendroglioma

A slowly growing tumour of the nervous system derived from neural connective tissue cells, the oligodendroglial cells. The cells of the tumour are small, well-defined ‘halo cells’ with round nuclei and clear CYTOPLASM.

oligodendroglioma, (ol´igōden´drōglēō´mə),

n a relatively rare, moderately well-differentiated, relatively slow-growing glioma that occurs most frequently in the cerebrum of adults. It is grossly homogeneous, fairly well-circumscribed, moderately firm, and somewhat gritty in consistency, with interstitial calcification sufficiently dense to allow detection by radiographic imaging of the skull.

oligodendroglioma

a neoplasm derived from and composed of oligodendroglia.
References in periodicals archive ?
Scope of this report: The report provides a snapshot of the global therapeutic landscape of Oligodendroglioma summarizing all the dormant and discontinued pipeline projects.
Coverage of the Oligodendroglioma pipeline on the basis of route of administration and molecule type.
They created the map by sequencing protein-coding genes in seven samples of tissue from oligodendroglioma tumors, and concentrated on recurring mutations in two genes (CIC and FUBP1) not previously associated with those types of tumors.
Washington, Jan 08 (ANI): A team of researchers have discovered the type of cell that is at the origin of brain tumors known as oligodendrogliomas, which are a type of glioma - a category that defines the most common type of malignant brain tumor.
20) supported this theory by demonstrating that pulmonary carcinoid tumors exhibited a gene expression profile similar to that of two neural-derived tumors, oligodendroglioma and high-grade astrocytoma.
Global Markets Direct's, 'Oligodendroglioma - Pipeline Review, H1 2012', provides an overview of the Oligodendroglioma therapeutic pipeline.
The CBTRUS estimates that the broad category glioma represents approximately 80% of malignant tumors and in patients between zero and 19 years of age, the overall total incidence of HGG (including anaplastic astrocytoma, anaplastic oligodendroglioma, glioblastoma, mixed glioma, and malignant glioma) is approximately 0.
The diagnosis was oligodendroglioma, World Health Organization (WHO) grade II.
The cause of the recurrent SAH is determined on imaging in only 50% of cases (3) and includes dural pathology, postsurgical CSF cavity with neovascularity, bleeding central nervous system (CNS) tumours (ependymoma, oligodendroglioma and astrocytoma), vascular malformations (arteriovenous malformations and cavernous malformation near the brain's surface), aneurysms, and in the spinal cord--tumours, arteriovenous malformations and traumatic nerve root avulsion.
64) Interestingly, MET uptake has been found to be greater in grade III oligodendroglioma than grade III astrocytoma, although the prognosis is generally better for oligodendroglial than for astrocytic tumors.
GlobalData's clinical trial report, Oligodendroglioma Global Clinical Trials Review, H1, 2012 provides data on the Oligodendroglioma clinical trial scenario.