oligodendrocyte


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oligodendroglia

 [ol″ĭ-go-den-drog´le-ah]
1. the non-neural cells of ectodermal origin forming part of the adventitial structure of the central nervous system.
2. the tissue composed of such cells.

ol·i·go·den·dro·cyte

(ol'i-gō-den'drō-sīt),
A cell of the oligodendroglia.

oligodendrocyte

/ol·i·go·den·dro·cyte/ (-den´dro-sīt) a cell of the oligodendroglia.

oligodendrocyte

(ŏl′ĭ-gō-dĕn′drə-sīt′, ō′lĭ-)
n.
One of the cells comprising the oligodendroglia.

oligodendrocyte

[ol′igōden′drəsīt]
Etymology: Gk, oligos + dendron, tree, kytos, cell
a type of neuroglial cell with dendritic projections that coil around axons of neural cells. The projections continue as myelin sheaths over the axons.

ol·i·go·den·dro·cyte

(ol'i-gō-den'drō-sīt)
A cell of the oligodendroglia.
Enlarge picture
OGLIODENDROCYTE

oligodendrocyte

(ol?i-go-den'tro-sit) [? + ? + kytos, cell]
A glial cell found most commonly in axon tracts; it myelinates axons in the central nervous system just as Schwann cells myelinate axons in the peripheral nervous system. Oligodendrocytes are neuroectodermal cells that originate from different precursors in the neural tube than astrocytes; later, stem cells in the subependymal layer can continue to generate new oligodendrocytes. Mature oligodendrocytes wrap neighboring axons in myelin, and some oligodendrocytes can simultaneously wrap many axons. However, not all oligodendrocytes myelinate axons.
Synonym: oligodendroglia See: illustration

oligodendrocyte

A connective cell of the central nervous system (glial cell) that participates in the formation of the myelin sheaths of nerve cell axons.

oligodendrocyte

a cell of oligodendroglia.
References in periodicals archive ?
No drugs exist that specifically and potently block M1 without affecting other muscarinic receptors, so the group continued using a genetic approach, employing knockout mice lacking the M1 receptor specifically in oligodendrocytes and testing these mice in the EAE model of MS.
This will allow us to look for therapies affecting not just motor neurons but also oligodendrocytes," says Lucie Bruijn, PhD, chief scientist, ALS Association.
Until now, OPCs and oligodendrocytes could only be obtained from fetal tissue or pluripotent stem cells.
Myelin oligodendrocyte glycoprotein induces experimental autoimmune encephalomyelitis in the "resistant" Brown Norway rat: disease susceptibility is determined by MHC and MHC-linked effects on the B cell response.
The development of oligodendrocytes, which are the myelin producing cells in the central nervous system, is dependent on TH, which aids proliferation and survival of oligodendrocyte preprogenitor cells (Barres et al.
Myelin sheaths are made by oligodendrocytes during nervous system development.
Multiple sclerosis occurs when the immune system attacks and kills myelin-forming oligodendrocytes, impeding nerve transmission and causing a variety of symptoms, including vision loss, numbness, muscle weakness and spasticity, mood swings, and cognitive decline.
Way's team has found that inhibiting the activity of eIF2-alpha reduces oligodendrocyte death, and boosting it increases oligodendrocyte death.
They showed in lab dishes that fingolimod could regulate many aspects of oligodendrocyte function or behavior, such as cell survival, differentiation, and extension toward nerve fibers.
To construct and maintain the fatty myelin insulation on nerve fibers, each oligodendrocyte wraps extensions around portions of nearby axons, and then layers a mixture of fat (80 percent) and protein (20 percent) over the fiber in segments separated by small gaps, or nodes.
MBP, an oligodendrocyte marker, is a major component of myelin and increases with oligodendrocyte differentiation and myelination, primarily during the second and third postnatal weeks in the rat (Wiggins 1986).
AST-OPC1 is an oligodendrocyte progenitor population derived from human embryonic stem cells originally isolated in 1998.