oligoclonal bands


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Related to oligoclonal bands: albuminocytologic dissociation

oligoclonal bands

Immunoglobulins found in the cerebrospinal fluid of patients with multiple sclerosis (MS) and, occasionally, in other neurological conditions. They are used as a marker of MS when magnetic resonance imaging studies of the brain are not diagnostic.
See also: band
References in periodicals archive ?
A family history, abdominal symptoms, Addisonian features and absent oligoclonal bands should prompt testing for very long chain fatty acids and/or leukocyte enzyme abnormalities.
Demyelinating lesion brain MRI, detection of oligoclonal bands and the presence of prior non-specific neurological symptoms increase the risk of CDMS
Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis.
Oligoclonal bands are rarely present in the cerebrospinal fluid and when observed, are transient.
1) In 2010, the College of American Pathologists (CAP) began offering a new proficiency survey on oligoclonal bands, OLI, which includes paired CSF and serum samples for laboratories performing these assays.
In addition to 1 year of disease progression, the new PPMS criteria require two of the following: at least one T2 lesion in at least one area characteristic for MS (periventricular, juxtacortical, or in-fratentorial); at least two T2 lesions in the cord; or positive cerebrospinal fluid (isoelectric focusing evidence of oligoclonal bands with or without an elevated IgG index).
Cerebrospinal fluid examination showed no oligoclonal bands and magnetic resonance imaging of the spine was normal.
CSF examination was again undertaken and was positive for oligoclonal bands.
the disease-causing abilities of antibodies found in the oligoclonal bands in the spinal fluid of people with MS
1 mg/dl, glucose 54 mg/dl (102 mg/dl in the serum), and an increased cerebrospinal fluid (CSF) IgG index without oligoclonal bands.
The CSF examination pointed to a demyelinating process in light of elevated IgG index and 2 unique oligoclonal bands.