oligoclonal banding

oligoclonal banding

[ol′igōklō′nəl]
a process by which cerebrospinal fluid IgG is distributed, after electrophoresis, in discrete bands. Approximately 90% of multiple sclerosis patients show oligoclonal banding.
References in periodicals archive ?
The diagnostic standard of care for MS includes cerebral spinal fluid analysis using the oligoclonal banding test alongside a comprehensive set of clinical tests to rule-out other neurological diseases.
It is good laboratory practice to perform oligoclonal banding analysis with parallel cerebrospinal fluid (CSF) and serum samples.
One of the hallmarks of MS, the oligoclonal banding (OCB) pattern in the CSF, has not been shown to be specific for most of the putative infectious agents, in contrast to their specificity in other known virological diseases.
In addition, at baseline, patients met at least one of three criteria: abnormal brain MRI, severe progression of cognitive impairment as shown by neuropsychological testing, or cerebrospinal fluid pleocytosis with or without intrathecal elevation of IgG synthesis and/or oligoclonal banding.
Measurement of 167 CSF specimens, deemed normal from negative oligoclonal banding and myelin basic protein results, produced an upper limit of the reference interval of 2.
Oligoclonal banding was absent and test for myelin basic protein was negati ve.
The CSF assay is designed to specifically detect and identify Ig-based oligoclonal banding in unconcentrated spinal fluid.
Lee KH, Hashimoto SA, Hooge JP et al: Magnetic resonance imaging of the head in the diagnosis of multiple sclerosis: A prospective 2-year follow-up with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT.
The results of this clinical study are consistent with two prior DioGenix studies, all of which compared MS Precise results both to published performance data for the oligoclonal banding test and experimental controls.
8) The oligoclonal banding pattern appears early during the course of MS and is therefore of great diagnostic help.
Oligoclonal banding of IgG in CSF, blood-brain barrier function, and MRI findings in patients with sarcoidosis, systemic lupus erythematosus, and Behcet's disease involving the nervous system.
A 39-year-old man who had a 6-year history of definite MS with supportive MRI scanning, positive oligoclonal banding in cerebrospinal fluid (CSF) and abnormal visual-evoked potentials, presented to the Emergency Department complaining of left leg weakness and of sustained flexion of all fingers in the left hand.