The CSF Ig-G index was within normal limits and negative CSF oligoclonal banding
The data is similar to findings from two previous DioGenix's trials comparing the product to performance results for the oligoclonal banding
(OCB) test and experimental controls.
It is good laboratory practice to perform oligoclonal banding
analysis with parallel cerebrospinal fluid (CSF) and serum samples.
One of the hallmarks of MS, the oligoclonal banding
(OCB) pattern in the CSF, has not been shown to be specific for most of the putative infectious agents, in contrast to their specificity in other known virological diseases.
Glucose was within normal range and there was no oligoclonal banding
In addition, at baseline, patients met at least one of three criteria: abnormal brain MRI, severe progression of cognitive impairment as shown by neuropsychological testing, or cerebrospinal fluid pleocytosis with or without intrathecal elevation of IgG synthesis and/or oligoclonal banding
Measurement of 167 CSF specimens, deemed normal from negative oligoclonal banding
and myelin basic protein results, produced an upper limit of the reference interval of 2.
was absent and test for myelin basic protein was negati ve.
The CSF assay is designed to specifically detect and identify Ig-based oligoclonal banding
in unconcentrated spinal fluid.
Lee KH, Hashimoto SA, Hooge JP et al: Magnetic resonance imaging of the head in the diagnosis of multiple sclerosis: A prospective 2-year follow-up with comparison of clinical evaluation, evoked potentials, oligoclonal banding
, and CT.
8) The oligoclonal banding
pattern appears early during the course of MS and is therefore of great diagnostic help.
of IgG in CSF, blood-brain barrier function, and MRI findings in patients with sarcoidosis, systemic lupus erythematosus, and Behcet's disease involving the nervous system.