The diagnostic standard of care for MS includes cerebral spinal fluid analysis using the oligoclonal banding
test alongside a comprehensive set of clinical tests to rule-out other neurological diseases.
It is good laboratory practice to perform oligoclonal banding
analysis with parallel cerebrospinal fluid (CSF) and serum samples.
One of the hallmarks of MS, the oligoclonal banding
(OCB) pattern in the CSF, has not been shown to be specific for most of the putative infectious agents, in contrast to their specificity in other known virological diseases.
In addition, at baseline, patients met at least one of three criteria: abnormal brain MRI, severe progression of cognitive impairment as shown by neuropsychological testing, or cerebrospinal fluid pleocytosis with or without intrathecal elevation of IgG synthesis and/or oligoclonal banding
Measurement of 167 CSF specimens, deemed normal from negative oligoclonal banding
and myelin basic protein results, produced an upper limit of the reference interval of 2.
was absent and test for myelin basic protein was negati ve.
The CSF assay is designed to specifically detect and identify Ig-based oligoclonal banding
in unconcentrated spinal fluid.
Lee KH, Hashimoto SA, Hooge JP et al: Magnetic resonance imaging of the head in the diagnosis of multiple sclerosis: A prospective 2-year follow-up with comparison of clinical evaluation, evoked potentials, oligoclonal banding
, and CT.
The results of this clinical study are consistent with two prior DioGenix studies, all of which compared MS Precise results both to published performance data for the oligoclonal banding
test and experimental controls.
8) The oligoclonal banding
pattern appears early during the course of MS and is therefore of great diagnostic help.
of IgG in CSF, blood-brain barrier function, and MRI findings in patients with sarcoidosis, systemic lupus erythematosus, and Behcet's disease involving the nervous system.
A 39-year-old man who had a 6-year history of definite MS with supportive MRI scanning, positive oligoclonal banding
in cerebrospinal fluid (CSF) and abnormal visual-evoked potentials, presented to the Emergency Department complaining of left leg weakness and of sustained flexion of all fingers in the left hand.