oligoclonal

oligoclonal

/ol·i·go·clo·nal/ (-klo´n'l) pertaining to or derived from only a few clones.

oligoclonal

adjective Referring to or derived from a small number of clones.
References in periodicals archive ?
In MS, this barrier breaks down, most often in the periventricular area, allowing activated T cells, B cells producing oligoclonal antibodies, and macrophages to enter myelinated areas of the brain and spinal cord.
announced today that it will present preclinical data on MM-151, an oligoclonal therapeutic consisting of a mixture of three human antibody antagonists, and MM-398, a nanoliposomal encapsulation of irinotecan, at the 14th World Conference on Lung Cancer, taking place July 3 - 7, 2011, in Amsterdam, The Netherlands.
When recurrent, this disease has in the past often been misclassified as MS, but it is a separate entity that is distinguished from MS by its severity, by disease location (it affects the optic nerves and extensive segments of the spinal cord, largely sparing the brain) and by cerebrospinal fluid (CSF) analysis (polymorphonuclear pleocytosis and absence of oligoclonal banding).
In the other patient, the tumor contained more than 1 band of episomal EBV DNA, suggesting an oligoclonal expansion despite the detection of only a single clone by immunoglobulin gene rearrangement analysis.
Our case was diagnosed with clinical definite MS according to the McDonald's criteria (20) with clinically observed two attacks, lesions fulfilling the criteria of dissemination in time and space on MRI, and the abnormal VEPs and SEPs despite the absence of oligoclonal bands in the CSF.
Reactive oligoclonal populations can also occur after transplantation that represent repopulation of the bone marrow and cannot be interpreted as reoccurrence of malignancy without reference to the original clone.
University of Colorado Health Sciences Center Project Title: Identification of Oligoclonal T Cell Populations in the Lungs of Patients with Severe Emphysema Teresa E.
5) Cerebrospinal fluid examination is largely unremarkable; however, pleocytosis and oligoclonal bands have been reported.
2) Although largely supplanted by MRI as a diagnostic tool, evidence of intrathecal synthesis of oligoclonal immunoglobulin is a characteristic and stable laboratory finding, present in over 90% of all MS patients, that is unaffected by immunomodulatory, immunosuppressive or other therapies.