Although the physiologic and morphologic effects of NYT and its components have been reported, little is known about the effect of NYT on olfactory nerve function.
Eight of the 16 mice were subjected to bilateral olfactory nerve transection (BNX group), and the remaining 8 mice underwent a sham surgery (sham group).
Fourteen mice were used to examine the effect of NYT on olfactory behavior during recovery from olfactory nerve transection.
The axons of the ORNs will regenerate through the olfactory nerve and enter the olfactory bulb (OB) of the CNS, where they will make new synaptic contacts [16-17].
Within the olfactory nerve, the OECs form cellular channels or tunnels through which large numbers of small-caliber nonmyelinated axons distribute through the olfactory nerve into the outer nerve layer (ONL) of the OB and extend into the olfactory glomeruli, where they make synapses (Figure 1) .
The issue of whether or not the solubilization of ultrafine Mn oxide was a prerequisite for its translocation along the olfactory nerve was still outstanding after the experiments described above.
The fact that occlusion of the right naris during inhalation for 2 days of the nanosized Mn oxide led to accumulation of Mn only in the left olfactory bulb confirmed that translocation from nasal deposits along the olfactory nerve accounts for this increase.
So there isn't a cure for people who are born with no olfactory nerves
or damaged ones," says Dr Girish Raheja, senior consultant, ENT, Indraprastha Apollo Hospital.
Prominent anti-caspase-3 staining was also present in olfactory nerve bundles (axons of OSNs) in the underlying lamina propria of the mice instilled with SG.
Remarkably, there were mild, widely scattered infiltrations of neutrophils in the remaining olfactory nerve bundles penetrating the bony cribiform plate that separates the nasal cavity and OB of the brain (Figure 8D).
However, axons from olfactory nerves
can get past barriers that other nerve cells can't.
The area of the brain that initially processes signals from the olfactory nerve
cells is called the olfactory bulb.