This study aims at understanding how dietary, ecological and evolutionary factors shape the anatomical design of the nose-to-brain olfactory
pathway in mammals.
By contrast, cellular replacement therapy holds promise for recovering olfactory
function that is impaired due to a wide range of causes.
The findings provide the first demonstration of functional olfactory
receptors in human taste cells, suggesting that olfactory
receptors may play a role in the taste system by interacting with taste receptor cells on the tongue.
The result of the study pushes scientific understanding of how the olfactory
system detects odors.
"In mice, olfactory
receptor genes are scattered across the genome at about 60 different locations -- on different chromosomes that are quite far apart from each other," said Kevin Monahan, PhD, a postdoctoral research scientist in the Lomvardas lab and the paper's co-first author.
Psychophysical tests are used to assess olfactory
identification (OI), olfactory
discrimination (OD), and the olfactory
As the scientists explain, previous research has shown that olfactory
brain receptors can pick up not only smell but also small variations in airflow, with different parts of the brain being activated upon inhalation and exhalation.
Although not an official diagnostic criterion, our patient met the provisional criteria set by the DSM-5 Anxiety, Obsessive-Compulsive Spectrum, Posttraumatic, and Dissociative Disorders Work Group criteria for Olfactory
Reference Syndrome :
KEY WORDS: Sinonasal tract, Olfactory
neuroblastoma, Esthesioneuroblastoma, Immunohistochemistry.
In a large cohort of de novo patients, it was reported that PD patients with hyposmia exhibit more severe motor symptoms and required greater levodopa-equivalent at a 2.5-year followup compared to those patients with normal olfactory
Similar results have been replicated in mice models.[sup] This scanning technology has also been used in AD patients and demonstrated classical glucose metabolic changes in temporal, parietal, posterior cingulate, and inferior parietal cortices.[sup], But these significant changes occur only years after the appearance of clinical symptoms.[sup], Up to date, no research has employed this promising technology to investigate the glucose metabolism of the olfactory
bulb in AD model mice.
In order to replace them, the body has Olfactory
Ensheathing Cells (OECs).