okadaic acid


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okadaic acid

(ō′kə-dā′ĭk)
n.
A toxin, C44H68O13, produced by dinoflagellates and found in certain edible mollusks that consume them. It can cause diarrhea and other gastrointestinal symptoms in humans.

okadaic acid

C44H68O13, a toxic acid found in shellfish. The toxin is produced by oceanic phytoplankton consumed by filter-feeding marine animals such as clams, crabs, and mussels and is the cause of diarrheal shellfish poisoning. Ingestion of these shellfish by humans results in profuse watery diarrhea.
CAS # 78111-17-8
See also: acid
References in periodicals archive ?
First US report of shellfish harvesting closures due to confirmed okadaic acid in Texas Gulf Coast oysters.
The toxins of the okadaic acid (OA) group, such as OA and dinophysistoxins (DTXs), are considered to be responsible for diarrhea.
Simultaneously, the real-time PCR for TNF-[alpha] inhibitory activity of the studied extracts in okadaic acid (OA) challenged A549 cells has been performed.
Unique features of the okadaic acid activity class tumor promoters.
okadaic acid and dinophysistoxins) cause similar reactions when injected intraperitoneally in mice, other extraction methods were established for their differentiation, but it is also evident that some desulfo YTXs were coextracted with okadaic acid and dinophysistoxins (Ciminiello et al.
To document that the activity measured as cpm reflected activity attributable to CaN and no other phosphatase, we added okadaic acid to the assay buffer to inhibit PP1 and PP2A.
Nevertheless, the method has been successfully implemented at ARL by Fenwick Laboratories scientist Julie Marr and Quilliam, and is used routinely to monitor okadaic acid in phytoplankton cultures.
Diarrhetic shellfish poisoning (DSP) such as okadaic acid and dinophysistoxin-1, and other lipophilic toxins such as pectenotoxin-2 (PTX2) and yessotoxin were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS).
Phosphatasc inhibition by okadaic acid results in an overall increase in protein phosphotylation and an imbalance in cell signaling that leads to toxicity.
32]P-serine-labeled 19-amino-acid peptide substrate (19mer) in the presence of okadaic acid, a phosphatase type 1 and 2A inhibitor, as described previously by Fruman et al.
We isolated five known kawapyrones (kavapyrones) (1~5) and a new additional kawapyrone, 7,8-epoxyyangonin (6), from kawa MeOH extract and subjected them to TNF-[alpha] (tumor necrosis factor-[alpha] release assay from BALB/3T3 cells treated with okadaic acid, a tumor promoter.
ABSTRACT This paper presents the results from an experiment, where uptake and elimination of diarrhetic shellfish toxins (DST) of the okadaic acid (OA) and pectenotoxin (PTX) groups were compared between blue mussels (Mytilus edulis) and European oysters (Ostrea edulis).