TRPM2

(redirected from oestrogen-responsive element-associated gene 1 protein)

TRPM2

A gene on chromosome 21q22.3 that encodes a nonselective,  voltage-independent cation channel, which mediates sodium and calcium ion influx in response to oxidative stress. TRPM2 is activated by ADP-ribose, NAD+, reactive oxygen species and arachidonic acid; it confers susceptibility to cell death in response to oxidative stress, and is inactivated by intracellular ATP.