oestrogen receptors

oestrogen receptors

Chemical groups to which oestrogens bind and which are commonly found in substantial quantities on breast cancers. The oestrogen receptor status of a woman with breast cancer is important because the prognosis is much worse in women with high levels of oestrogen receptor alpha than in those with oestrogen alpha negative cancers. The status can easily and cheaply be determined by gene expression micro array analysis. 70 to 80 per cent of breast cancers are oestrogen receptor alpha positive. Tamoxifen, which has substantially reduced breast cancer mortality, is now regarded as an oestrogen receptor modulator.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Oestrogen receptor knockout mice: roles for oestrogen receptors alpha and beta in reproductive tissues.
Dominant expression and distribution of oestrogen receptor beta over oestrogen receptor alpha in the human corpus luteum.
Patients younger than 53 years of age with Grade II and III infiltrating ductal carcinoma also had significantly lower levels of oestrogen receptors, but not of progesterone receptors when compared with those patients older than 53 years of age.
with Grade II and III have lower level of oestrogen receptors, both not of progesterone receptors.
Berman, "Role of the oestrogen receptors GPR30 and ER[alpha] in peripheral sensitization: relevance to trigeminal pain disorders in women," Cephalalgia, vol.
Kim et al., "Exploiting the apoptotic actions of oestrogen to reverse antihormonal drug resistance in oestrogen receptor positive breast cancer patients," Breast, vol.
Oestrogen has recipient molecules known as oestrogen receptors, which cause the body to respond to oestrogen.
In order to develop an oestrogen treatment that utilises the favourable effects of the oestrogen but not its side-effects, researchers at the Sahlgrenska Academy, University of Gothenburg, Sweden, have analysed which parts of the oestrogen receptor is most important in enabling oestrogen to act on bone tissue and other tissues.
Nuclear and extranuclear pathway inputs in the regulation of global gene expression by oestrogen receptors. Mol Endocrinol, 2008, 22, 2116-2127.
Almost two-thirds of breast cancer tumours from pre-menopausal women and three-quarters of those from post-menopausal women contain detectable oestrogen receptors.
Human oestrogen receptor cDNA: sequence, expression and homology to v-ERP-A.