oestrogen receptors

oestrogen receptors

Chemical groups to which oestrogens bind and which are commonly found in substantial quantities on breast cancers. The oestrogen receptor status of a woman with breast cancer is important because the prognosis is much worse in women with high levels of oestrogen receptor alpha than in those with oestrogen alpha negative cancers. The status can easily and cheaply be determined by gene expression micro array analysis. 70 to 80 per cent of breast cancers are oestrogen receptor alpha positive. Tamoxifen, which has substantially reduced breast cancer mortality, is now regarded as an oestrogen receptor modulator.
References in periodicals archive ?
Oestrogen receptor knockout mice: roles for oestrogen receptors alpha and beta in reproductive tissues.
Dominant expression and distribution of oestrogen receptor beta over oestrogen receptor alpha in the human corpus luteum.
Patients younger than 53 years of age with Grade II and III infiltrating ductal carcinoma also had significantly lower levels of oestrogen receptors, but not of progesterone receptors when compared with those patients older than 53 years of age.
Here the study is done between the tumour size and the oestrogen receptor status, in this study most of the women had tumour in the range of 2-5 cms and as the size of the tumour increased the oestrogen receptors negativity has increased.
with Grade II and III have lower level of oestrogen receptors, both not of progesterone receptors.
Oestrogen has recipient molecules known as oestrogen receptors, which cause the body to respond to oestrogen.
In order to develop an oestrogen treatment that utilises the favourable effects of the oestrogen but not its side-effects, researchers at the Sahlgrenska Academy, University of Gothenburg, Sweden, have analysed which parts of the oestrogen receptor is most important in enabling oestrogen to act on bone tissue and other tissues.
This is the first study to analyse the significance of different parts of a particular type of oestrogen receptor through studies in mice.
2+] signals in ciliary neurons through classical oestrogen receptors in cytoplasm.
A G[alpha]s protein-coupled membrane receptor, distinct from the classical oestrogen receptor, transduces rapid effects from oestradiol on [[[Ca.
Human oestrogen receptor cDNA: sequence, expression and homology to v-ERP-A.
The chicken oestrogen receptor sequence: Homology with v-erbA and the human oestrogen and glucocorticoid receptors.