Osteocalcin, a vitamin K-dependent noncollagenous extracellular matrix protein, is synthesized by osteoblasts and odontoblasts
Deficiencies in magnesium can result in changes in ameloblasts and odontoblasts
as well as hypoplasia of enamel and dentin.
It is hypothesized that the stage-specific signaling differences between the primary and secondary knot is responsible for altering odontoblast
differentiation, patterning, and morphogenesis in order to develop the appropriate dental anatomy for each tooth [Thesleff et al.
Relative levels of mRNA encoding enamel proteins in enamel organ epithelia and odontoblasts
Once the pattern has been laid out, the spine's interior could then be strengthened by dentin deposition from odontoblasts
derived from the prevalent mesenchyme-like cells located within the pulp of the developing spine.
It is synthesized only by osteoblasts and odontoblasts
, with a small amount released de novo into the circulation (2).
Functional studies have demonstrated that DMP1 is essential in the maturation of odontoblasts
and osteoblasts, as well as in mineralisation via local and systemic mechanisms [Feng et al.
1976]; poorly calcified dentinal bridges and few residual odontoblasts
have been reported [Agamy et al.
Sicher and Bhaskar  suggested that disturbances during the morphodifferentiation stage, such as altered endocrinic function, may affect the shape and size of the tooth without impairing the function of the ameloblasts and odontoblasts