Clebopride has been reported to cause acute events as hypertonic reaction in children  and oculogyric
crisis in young adults , but only one case of acute hemifacial dystonia was observed in adults .
([dagger]) EPS includes bradykinesia, cogwheel rigidity, drooling, dystonia, extrapyramidal disorder, glabellar reflex abnormal, hypokinesia, muscle rigidity, oculogyric
crisis, oromandibular dystonia, parkinsonism, psychomotor retardation, tongue spasm, torticollis, tremor, and trismus.
When the atypical antipsychotics are compared to typical ones, dystonic reactions and therefore cause of oculogyric
crisis are not expected.
Just recently, Food and Drug Administration (FDA) associated cetirizine with potential signs of severe risk for oculogyric
crisis.2 A retrospective study has established that cetirizine causes oculogyric
complications particularly in the paediatric population (8 paediatric cases out of a total of 9 cases) with dosage extending from 5 to 10mg and commencement of symptoms varying from 3 to 184 days.3 Confirmed rechallenge data were seen in 6 cases of oculogyric
crisis while 8 cases underwent thorough neurologic consultation with radiographic proceedings.
cogwheel rigidity, drooling, dystonia, extrapyramidal disorder, hypokinesia, muscle rigidity, oculogyric
crisis, oromandibular dystonia, parkinsonism, psychomotor retardation, tongue spasm, torticollis, tremor and trismus **Somnolence includes adverse event terms: hypersomnia, hypersomnolence, sedation, and somnolence
crisis (OGC) is a type of acute dystonic reaction which is usually a side effect of an antipsychotic treatment.
Maculopathy, (5) oculogyric
crisis, (6) nystagm us, prop toms, and papilloedema.
I am a simple bar-tender, heir to a monosyllabic sailor who was down to his last eye when he came ashore (I concede that this was an extremely expressive eye, capable of oculogyric
fireworks and withering glares).
Common signs of these diseases include hypotonia (low muscle tone); rigidity; movement disorders (i.e., tremors or dystonia); oculogyric
crises (abnormal eye movements); temperature instability; profuse sweating; absence of speech; and developmental delay.
Overdoses of tetrabenazine ranging from 100 to 1,000 mg have been reported in the literature and were associated with acute dystonia, oculogyric
crisis, nausea and vomiting, sweating, sedation, hypotension, confusion, diarrhea, hallucinations, rubor, and tremor.
Table 18: Incidence of EPS Compared to Placebo in the Monotherapy Bipolar Depression Study LATUDA 20 to 60 80 to 120 Placebo mg/day mg/day (N=168) (N=164) (N=167) Adverse Event Term (%) (%) (%) All EPS events 5 12 20 All EPS events, excluding Akathisia/ 2 5 9 Restlessness Akathisia 2 8 11 Dystonia * 0 0 2 Parkinsonism ** 2 5 8 Restlessness <1 0 3 Note: Figures rounded to the nearest integer * Dystonia includes adverse event terms: dystonia, oculogyric
crisis, oromandibular dystonia, tongue spasm, torticollis, and trismus ** Parkinsonism includes adverse event terms: bradykinesia, cogwheel rigidity, drooling, extrapyramidal disorder, glabellar reflex abnormal, hypokinesia, muscle rigidity, parkinsonism, psychomotor retardation, and tremor Adjunctive Therapy with Lithium or Valproate
ADR in form of oculogyric
crises and hyperprolactinemia was reported in 2 patients of each group.