ochronosis

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ochronosis

 [ok″ro-no´sis]
a peculiar discoloration of body tissues caused by deposit of alkapton bodies as the result of a metabolic disorder.
ocular ochronosis brown or gray discoloration of the sclera, sometimes involving also the conjunctivae and eyelids.

o·chron·o·sis

(ō'kron-ō'sis),
A rare, autosomal recessive disease characterized by alkaptonuria with pigmentation of the cartilages and sometimes tissues such as muscle, epithelial cells, and dense connective tissue; may affect also the sclera, mucous membrane of the lips, and skin of the ears, face, and hands, and cause standing urine to be dark colored and contain pigmented casts; pigmentation is thought to result from oxidized homogentisic acid, and cartilage degeneration results in osteoarthritis, particularly of the spine.
[G. ōchros, pale yellow, + nosos, disease]

ochronosis

Alkaptonuria, see there.

o·chro·no·sis

(ō'kron-ō'sis)
A condition observed in people with alkaptonuria, characterized by pigmentation of the cartilages; also may affect the sclerae, mucous membrane of the lips, and skin of the ears, face, and hands and may cause standing urine to be dark and contain pigmented casts; pigmentation results from oxidized homogentisic acid; cartilage degeneration results in osteoarthritis.
[G. ōchros, pale yellow, + nosos, disease]

ochronosis

Persistent joint disease associated with blue or brownish discoloration of the joint cartilages occurring in patients with ALKAPTONURIA.

ochronosis

People with this rare hereditary condition tend to develop arthritis in adulthood.
Mentioned in: Pseudogout