ocular melanocytosis

Ocular melanocytosis

A congenital eye disorder featuring diffuse hyperplasia of melanocytes causing darkening of the iris of the affected eye especially at the pupil margin, brownish discolouration of the episclera, darkening of the fundus, and an increased risk of developing melanomas and GLAUCOMA.

melanocytosis, ocular

A congenital, usually unilateral lesion, characterized by slate grey areas of increased pigmentation. The pigment is curiously not found in the conjunctival epithelium, but is located in the uvea, sclera and episcleral tissues. It may predispose the individual to uveal melanoma. Syn. congenital melanosis oculi. See naevus of Ota.
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References in periodicals archive ?
16) It can be divided clinically into ocular melanocytosis and oculodermal melanocytosis (Naevus of Ota), the latter referring to when the periocular skin is also affected (unilaterally), most commonly in the distribution of the first and second divisions of the trigeminal nerve.
Congenital ocular melanocytosis predisposes to uveal melanoma, as well as melanoma of the ipsilateral skin, orbit, optic nerve head and brain.
In a large clinical series, (5) 8 of 4500 patients presented with bilateral melanoma; no specific syndrome was identified other than ocular melanocytosis for 2 patients.